Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease
JJM Van Dongen, EA Macintyre, JA Gabert… - Leukemia, 1999 - nature.com
Prospective studies on the detection of minimal residual disease (MRD) in acute leukemia
patients have shown that large-scale MRD studies are feasible and that clinically relevant …
patients have shown that large-scale MRD studies are feasible and that clinically relevant …
Bcr–Abl variants: biological and clinical aspects
AS Advani, AM Pendergast - Leukemia research, 2002 - Elsevier
Bcr–Abl is an oncogene that arises from fusion of the Bcr gene with the c-Abl proto-
oncogene. Three different Bcr–Abl variants can be formed, depending on the amount of Bcr …
oncogene. Three different Bcr–Abl variants can be formed, depending on the amount of Bcr …
Neutrophilic-chronic myeloid leukemia: a distinct disease with a specific molecular marker (BCR/ABL with C3/A2 junction)[see comments]
F Pane, F Frigeri, M Sindona, L Luciano, F Ferrara… - 1996 - ashpublications.org
Neutrophilic-chronic myeloid leukemia (CML-N) is a rare myeloproliferative disorder that
runs a much more benign course than chronic myeloid leukemia, and for which no specific …
runs a much more benign course than chronic myeloid leukemia, and for which no specific …
Biology of chronic myelogenous leukemia—signaling pathways of initiation and transformation
JV Melo, MWN Deininger - Hematology/Oncology Clinics, 2004 - hemonc.theclinics.com
The mechanisms responsible for the t (9; 22)(q34; q11) reciprocal chromosomal
translocation that generates the Philadelphia chromosome (Ph) remain elusive. One view is …
translocation that generates the Philadelphia chromosome (Ph) remain elusive. One view is …
5′ CpG island hypermethylation is associated with transcriptional silencing of the p21CIP1/WAF1/SDI1 gene and confers poor prognosis in acute lymphoblastic …
J Roman-Gomez, JA Castillejo… - Blood, The Journal …, 2002 - ashpublications.org
The p21 is a downstream effector of p53/p73 and belongs to the CIP/KIP family of cyclin-
dependent kinase inhibitors (CDKIs). It is, therefore, a potential tumor suppressor gene and …
dependent kinase inhibitors (CDKIs). It is, therefore, a potential tumor suppressor gene and …
BCR/ABL genes and leukemic phenotype: from molecular mechanisms to clinical correlations
F Pane, M Intrieri, C Quintarelli, B Izzo, GC Muccioli… - Oncogene, 2002 - nature.com
Abstract The Philadelphia chromosome (Ph), a minute chromosome that derives from the
balanced translocation between chromosomes 9 and 22, was first described in 1960 and …
balanced translocation between chromosomes 9 and 22, was first described in 1960 and …
2 BCR-ABL gene variants
JV Melo - Baillière's clinical haematology, 1997 - Elsevier
The BCR-ABL hybrid gene, the main product of the t (9; 22)(q34; q11) translocation, is found
in the leukaemic clone of at least 95% of CML patients. The fusion protein encoded by BCR …
in the leukaemic clone of at least 95% of CML patients. The fusion protein encoded by BCR …
Recognition of BCR-ABL positive leukemic blasts by human CD4+ T cells elicited by primary in vitro immunization with a BCR-ABL breakpoint peptide
GJ Bosch, AM Joosten, JH Kessler, CJ Melief… - 1996 - ashpublications.org
In chronic myeloid leukemia (CML) the classical 9; 22 translocation results in a BCR-ABL
fusion gene, which encodes chimeric BCR-ABL fusion 210 kD oncoproteins (p210BCR …
fusion gene, which encodes chimeric BCR-ABL fusion 210 kD oncoproteins (p210BCR …
Localisation and distance between ABL and BCR genes in interphase nuclei of bone marrow cells of control donors and patients with chronic myeloid leukaemia
E Lukášová, S Kozubek, M Kozubek, J Kjeronská… - Human genetics, 1997 - Springer
Quantitative measurements of the nuclear localisation of the ABL and BCR genes and the
distance between them were performed in randomly oriented bone marrow cells of control …
distance between them were performed in randomly oriented bone marrow cells of control …
Philadelphia Chromosome–Positive Acute Lymphocytic Leukemia
JP Radich - Hematology/oncology clinics of North America, 2001 - Elsevier
The Philadelphia (Ph) chromosome was the first cancer-specific translocation discovered.
44 It is the hallmark genetic lesion found in chronic myeloid leukemia (CML), is found less …
44 It is the hallmark genetic lesion found in chronic myeloid leukemia (CML), is found less …