Mpox multi-antigen mRNA vaccine candidates by a simplified manufacturing strategy afford efficient protection against lethal orthopoxvirus challenge

J Zeng, Y Li, L Jiang, L Luo, Y Wang… - Emerging microbes & …, 2023 - Taylor & Francis
Current unprecedented mpox outbreaks in non-endemic regions represent a global public
health concern. Although two live-attenuated vaccinia virus (VACV)-based vaccines have …

A literature review on current practices, knowledge, and viewpoints on pentobarbital euthanasia performed by veterinarians and animal remains disposal in the United …

NS Kollias, WJ Hess, CL Johnson… - Journal of the …, 2023 - Am Vet Med Assoc
Sodium pentobarbital and pentobarbital combination products are commonly used by
veterinarians throughout the US for euthanasia of their animal patients. The AVMA …

Antibiotic-induced gut microbiota dysbiosis has a functional impact on purine metabolism

X Liu, L Ke, K Lei, Q Yu, W Zhang, C Li, Z Tian - BMC microbiology, 2023 - Springer
Background Dysbiosis of the gut microbiota is closely linked to hyperuricemia. However, the
effect of the microbiome on uric acid (UA) metabolism remains unclear. This study aimed to …

Commonly overlooked factors in biocompatibility studies of neural implants

LS Kumosa - Advanced Science, 2023 - Wiley Online Library
Biocompatibility of cutting‐edge neural implants, surgical tools and techniques, and
therapeutic technologies is a challenging concept that can be easily misjudged. For …

[HTML][HTML] Temperature-induced Artifacts in Tau Phosphorylation: Implications for Reliable Alzheimer's Disease Research

G Canet, E Rocaboy, F Laliberté… - Experimental …, 2023 - ncbi.nlm.nih.gov
In preclinical research on Alzheimer's disease and related tauopathies, tau phosphorylation
analysis is routinely employed in both cellular and animal models. However, recognizing the …

Promising drug candidates for the treatment of polycystic ovary syndrome (PCOS) as alternatives to the classical medication metformin

HS Anbar, NY Vahora, H laghman Shah… - European Journal of …, 2023 - Elsevier
Polycystic ovary syndrome (PCOS) is a prevalent hormonal disorder that affects women of
reproductive age. It is characterized by abnormal production of androgens, typically present …

Argel's stemmoside C as a novel natural remedy for mice with alcohol-induced gastric ulcer based on its molecular mechanistic pathways

G Nabil, YH Ahmed, O Ahmed, SS Milad… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Solenostemma argel is widely distributed in Africa & Asia
with traditional usage in alleviating abdominal colic, aches, & cramps. This plant is rich in …

Knockdown of polypyrimidine tract binding protein facilitates motor function recovery after spinal cord injury

RY Yang, R Chai, JY Pan, JY Bao, PH Xia… - Neural Regeneration …, 2023 - journals.lww.com
After spinal cord injury (SCI), a fibroblast-and microglia-mediated fibrotic scar is formed in
the lesion core, and a glial scar is formed around the fibrotic scar as a result of the activation …

Isolation and culture of neonatal murine primary cardiomyocytes

V Ravi, A Jain, A Taneja, K Chatterjee… - Current …, 2021 - Wiley Online Library
The cardiomyocyte is the main cell type in the heart responsible for its contractile function.
Culturing primary cardiomyocytes from mammalian sources to study their function remains …

Impact of the functional coating of silver nanoparticles on their in vivo performance and biosafety

HM Tawfeek, MA Younis, BN Aldosari… - Drug Development …, 2023 - Taylor & Francis
Objective and significance Silver nanoparticles (AgNPs) have become an interesting
therapeutic modality and drug delivery platform. Herein, we aimed to investigate the impact …