Three processes act in series to accurately replicate the eukaryotic nuclear genome. The
major replicative DNA polymerases strongly prevent mismatch formation, occasional …

The early notion that cancer is caused by mutations in genes critical for the control of cell
growth implied that genome stability is important for preventing oncogenesis. During the …

Artificial intelligence-based protein structure prediction approaches have had a
transformative effect on biomolecular sciences. The predicted protein models in the …

Structural maintenance of chromosomes (SMC) protein complexes structure genomes by
extruding DNA loops, but the molecular mechanism that underlies their activity has …

Summary Poly (ADP-ribose) polymerase 1 (PARP-1) is a key eukaryotic stress sensor that
responds in seconds to DNA single-strand breaks (SSBs), the most frequent genomic …

DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role
in maintaining genomic stability. The specificity of MMR is primarily for base-base …

The concept of mismatch repair (MMR) was formulated independently in 1964 to explain the
removal of brominated nucleotides from DNA as well as gene conversion during genetic …

The present advances in biology are related to progress in genomics, proteomics, and other
“-omics”, including glycomics, working with a large amount of data regarding human and …

By removing biosynthetic errors from newly synthesized DNA, mismatch repair (MMR)
improves the fidelity of DNA replication by several orders of magnitude. Loss of MMR brings …

▪ Abstract DNA mismatch repair (MMR) is an evolutionarily conserved process that corrects
mismatches generated during DNA replication and escape proofreading. MMR proteins also …