Colorectal cancer (CRC) is the third most common diagnosed malignancy among both
sexes in the United States as well as in the European Union. While the incidence and …

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide,
with high rates of recurrence and death. Surgical resection and ablation therapy have limited …

Human cholangiocyte organoids are promising for regenerative medicine applications, such
as repair of damaged bile ducts. However, organoids are typically cultured in mouse tumor …

Simple Summary Hepatocellular carcinoma (HCC) is a highly incident and deadly malignant
neoplasia, and only a few anti-HCC drugs are currently available. Thus, the development of …

Simple Summary Hepatocellular carcinoma (HCC) is characterized by a broad molecular
and genetic heterogeneity, which makes it a challenging subject in terms of the underlying …

Cholangiocarcinoma is characterized by a poor prognosis with limited treatment and
management options. Chemotherapy using gemcitabine with cisplatin is the only available …

Tremendous advances have been made toward accurate recapitulation of the human
intestinal system in vitro to understand its developmental process, and disease progression …

Tumor initiation and progression are critically dependent on interaction of cancer cells with
their cellular and extracellular microenvironment. Alterations in the composition, integrity …

Organoid technology holds great promise for regenerative medicine. Recent studies show
feasibility for bile duct tissue repair in humans by successfully transplanting cholangiocyte …

MicroRNA (miRNA) imaging has been employed to distinguish cancer cells from normal
cells by exploiting the overexpression of miRNA in cancer. Inspired by the acidic …