HIV employs multiple means to evade the humoral immune response, particularly the
elicitation of and recognition by broadly neutralizing antibodies (bnAbs). Such antibodies …

Combination anti-retroviral therapy (ART) has revolutionized the treatment and prevention of
HIV-1 infection. Taken daily, ART prevents and suppresses the infection. However, ART …

Antibody responses to the HIV-1 envelope glycoproteins can be classified into three groups.
Binding but non-neutralizing responses are directed to epitopes that are expressed on …

Broadly neutralizing antibodies against highly variable viral pathogens are much sought
after to treat or protect against global circulating viruses. Here we probed the neutralizing …

Despite the success of potent anti-retroviral drugs in controlling human immunodeficiency
virus type 1 (HIV-1) infection, little progress has been made in generating an effective HIV-1 …

Neutralizing antibodies can confer immunity to primate lentiviruses by blocking infection in
macaque models of AIDS,,,. However, earlier studies of anti-human immunodeficiency virus …

Most animal studies using passive administration of HIV broadly neutralizing monoclonal
antibodies (bnMAbs) have associated protection against high-dose mucosal viral challenge …

It is widely appreciated that effective human vaccines directed against viral pathogens elicit
neutralizing antibodies (NAbs). The passive transfer of anti–HIV-1 NAbs conferring …

A recombinant virus assay was used to characterize in detail neutralizing antibody
responses directed at circulating autologous HIV in plasma. Examining serial plasma …

Neutralizing antibodies are crucial for vaccine-mediated protection against viral diseases.
They probably act, in most cases, by blunting the infection, which is then resolved by cellular …