Cancer stem cells (CSCs) are considered to be responsible for tumor recurrence and
metastasis. Therefore, clarification of the mechanisms involved in CSC stemness …

In the pursuit of bioactive phytochemicals as a therapeutic strategy to manage metabolic risk
factors for type 2 diabetes (T2D), aspalathin, C-glucosyl dihydrochalcone from rooibos …

Drug resistance remains a barrier in the clinical treatment of ovarian cancer. Proteasomal
and antioxidant activities play important roles in tumor drug resistance, and increasing …

Simple Summary Cannabidiol (CBD) is a phytocannabinoid from Cannabis sativa L. that
exhibits no psychoactivity and, like the psychoactive cannabinoid Δ9-tetrahydrocannabinol …

Oral potentially malignant disorders (OPMDs) are precursors of oral squamous cell
carcinoma (OSCC). Deregulated cellular energy metabolism is a critical hallmark of cancer …

The receptor kinase c-MET has emerged as a target for glioblastoma therapy. However,
treatment resistance emerges inevitably. Here, we performed global metabolite screening …

Cancer cells depend on metabolic reprogramming for survival, undergoing profound shifts in
nutrient sensing, nutrient uptake and flux through anabolic pathways, in order to drive …

Background Renal fibrosis is a common pathological endpoint in CKD that is challenging to
reverse, and myofibroblasts are responsible for the accumulation of a fibrillar collagen-rich …

Background Glutaminase isoenzymes GLS and GLS2 play apparently opposing roles in
cancer: GLS acts as an oncoprotein, while GLS2 (GAB isoform) has context specific tumour …

The integrated stress response (ISR) is a central cellular adaptive program that is activated
by diverse stressors including ER stress, hypoxia and nutrient deprivation to orchestrate …