The severe acute respiratory syndrome coronavirus-2 emerged as a serious human
pathogen in late 2019, causing the disease coronavirus disease 2019 (COVID-19). The …

Rationale: Diaphragm dysfunction worsens outcomes in mechanically ventilated patients,
but the clinical impact of potentially preventable changes in diaphragm structure and …

Mechanical ventilation can cause acute diaphragm atrophy and injury, and this is associated
with poor clinical outcomes. Although the importance and impact of lung-protective …

Abstract Purpose Esophageal pressure (Pes) is a minimally invasive advanced respiratory
monitoring method with the potential to guide management of ventilation support and …

Rationale: Diaphragm atrophy and dysfunction have been reported in humans during
mechanical ventilation, but the prevalence, causes, and functional impact of changes in …

Diaphragm weakness is highly prevalent in critically ill patients. It may exist prior to ICU
admission and may precipitate the need for mechanical ventilation but it also frequently …

Several mechanisms of diaphragm muscle injury (myotrauma) can result in ventilator-
induced diaphragm dysfunction, including ventilator over-assistance, under-assistance …

Rationale: Diaphragmatic function is a major determinant of the ability to successfully wean
patients from mechanical ventilation (MV). Paradoxically, MV itself results in a rapid loss of …

Rationale: Monitoring and controlling respiratory drive and effort may help to minimize lung
and diaphragm injury. Airway occlusion pressure (P0. 1) is a noninvasive measure of …

Background Excessive respiratory muscle effort during mechanical ventilation may cause
patient self-inflicted lung injury and load-induced diaphragm myotrauma, but there are no …