Oxidative stress is a feature of many chronic inflammatory diseases. Such diseases are
associated with up-regulation of a vitamin B12 (cobalamin) blood transport protein and its …

Abstract Cobalamin (Cbl, vitamin B12) deficiency in humans is a cause of hematologic and
neurologic disorders. We show here that the cellular export of Cbl, in contrast to the carrier …

Nutritional deficiency and genetic errors that impair the transport, absorption, and utilization
of vitamin B 12 (B 12) lead to hematological and neurological manifestations. The cblC …

The CblC and CblD chaperones are involved in early steps in the cobalamin trafficking
pathway. Cobalamin derivatives entering the cytoplasm are converted by CblC to a common …

The chemical properties of disulfides are leveraged in a wide array of applications, ranging
from protein–drug conjugates for cancer treatment to self-healing materials. However …

Background: Accurate assessment of cobalamin profiles in human serum, cells, and tissues
may have clinical diagnostic value. However, non-alkyl forms of cobalamin undergo β-axial …

Food additives, such as hypochlorous acid water, sodium metabisulfite, and sodium sulfite,
strongly affect the chemical and biological properties of vitamin B12 (cyanocobalamin) in …

In humans, cobalamin or vitamin B 12 is delivered to two target enzymes via a complex
intracellular trafficking pathway comprising transporters and chaperones. CblC (or …

Cobalamin is an essential nutrient required for the normal functioning of cells. Its deficiency
can lead to various pathological states. Hydroxocobalamin (HOCbl) and cyanocobalamin …

We report the first studies on the reaction between an HNO donor compound and vitamin
B12 complexes. Kinetic and mechanistic studies have been carried out on the reaction …