Three‐dimensional cell culture models, such as spheroids, can be used in the process of the
development of new anticancer agents because they are able to closely mimic the main …

Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …

Background Pancreatic ductal adenocarcinoma (PDAC) is the fourth most common cause of
cancer related death. It is lethal in nearly all patients, due to an almost complete …

For analysis of multidrug resistance, a major barrier to effective cancer chemotherapy, we
profiled mRNA expression of the 48 known human ABC transporters in 60 diverse cancer …

Increasing chemotherapy delivery to tumors, while enhancing drug uptake and reducing
side effects, is a primary goal of cancer research. In mouse and human cancer models in …

When cancer cells develop resistance to chemotherapeutics, it is frequently conferred by the
ATP-dependent efflux pump P-glycoprotein (MDR1, P-gp, ABCB1). P-gp can efflux a wide …

Despite a growing interest in development of non-cytotoxic targeted agents, systemic
chemotherapy is still the mainstay of treatment for both non-small cell lung cancer (NSCLC) …

Overexpression of ATP-binding cassette (ABC) drug transporters that actively efflux a variety
of amphipathic compounds can cause multidrug resistance (MDR) in cancer cells, which is a …

While chemotherapy provides useful palliation, advanced lung cancer remains incurable
since those tumors that are initially sensitive to therapy rapidly develop acquired resistance …

Aim Pancreatic cancer (PC) is one of the most aggressive tumors with dismal survival and a
high death rate due to chemotherapeutic failure. P-glycoprotein (P-gp) plays a pivotal role in …