Abnormal placentation is considered as an underlying cause of various pregnancy
complications such as miscarriage, preeclampsia and intrauterine growth restriction, the …

Stem cell niches are specialized microenvironments that promote the maintenance of stem
cells and regulate their function. Recent advances have improved our understanding of the …

The ontogeny of human haematopoietic stem cells (HSCs) is poorly defined owing to the
inability to identify HSCs as they emerge and mature at different haematopoietic sites. Here …

The extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the
developing embryo but remains ill-defined in humans. We therefore assembled a …

The hematopoietic stem cell (HSC) niche commonly refers to the pairing of hematopoietic
and mesenchymal cell populations that regulate HSC self-renewal, differentiation, and …

In adult mammals, hematopoietic stem cells (HSCs) are defined by their abilities to self‐
renew and to differentiate to form all blood cell lineages. These rare multipotent cells occupy …

Stem cell therapy holds the promise to treat degenerative diseases, cancer and repair of
damaged tissues for which there are currently no or limited therapeutic options. The …

Hematopoietic stem cells (HSCs) develop in discrete anatomical niches, migrating during
embryogenesis from the aorta-gonad-mesonephros (AGM) region to the fetal liver, and …

Stem cell niches are composed of dynamic microenvironments that support stem cells over a
lifetime. The emerging niche is distinct from the adult because its main role is to support the …

Now available in a thoroughly revised Twelfth Edition, Wintrobe's Clinical Hematology
continues to be an industry leader with its ability to correlate basic science with the clinical …