Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

Tissue injury triggers a complex series of cellular responses, starting from inflammation
activated by tissue and cell damage and proceeding to healing. By clearing cell debris …

Oxidative stress and inflammation interact in the development of diabetic atherosclerosis.
Intracellular hyperglycemia promotes production of mitochondrial reactive oxygen species …

The AMP-activated protein kinase (AMPK) is a central regulator of multiple metabolic
pathways and may have therapeutic importance for treating obesity, insulin resistance, type …

The intestinal immune system is continuously exposed to massive amounts of nanoparticles
derived from food. Whether nanoparticles from plants we eat daily have a role in maintaining …

The AMP-activated protein kinase (AMPK) is a key regulator of cellular and whole-body
energy homeostasis, which acts to restore energy homoeostasis whenever cellular energy …

Heart failure is one of the leading causes of death and disability worldwide. Left ventricle
remodeling, fibrosis, and ischemia/reperfusion injury all contribute to the deterioration of …

The primary cilium projects from the surface of most vertebrate cells, where it senses
extracellular signals to regulate diverse cellular processes during tissue development and …

Objective Previous mechanistic studies on immunometabolism have focused on metabolite-
based paradigms of regulation, such as itaconate. Here, we, demonstrate integration of …

Diabetic nephropathy (DN), a kind of microvascular complication, is a primary cause of end-
stage renal disease worldwide. However, therapeutic drugs for DN treatment are still in lack …