ERK signaling for cell migration and invasion
SC Samson, AM Khan, MC Mendoza - Frontiers in molecular …, 2022 - frontiersin.org
The RAS-Extracellular signal-regulated kinase (RAS-ERK) pathway plays a conserved role
in promoting cell migration and invasion. Growth factors, adhesion, and oncogenes activate …
in promoting cell migration and invasion. Growth factors, adhesion, and oncogenes activate …
[HTML][HTML] Stretching the limits of extracellular signal-related kinase (ERK) signaling—cell mechanosensing to ERK activation
Extracellular signal-regulated kinase (ERK) has been recognized as a critical regulator in
various physiological and pathological processes. Extensive research has elucidated the …
various physiological and pathological processes. Extensive research has elucidated the …
Biomimetic fibers derived from an equidistant micropillar platform dictate osteocyte fate via mechanoreception
Y Liu, X Pu, M Duan, C Chen, Y Zhao, D Zhang… - Nano Letters, 2023 - ACS Publications
It is a big challenge to design a biomimetic physical microenvironment with greater similarity
to in vivo tissue to observe real cell behaviors. We established a novel cell culture platform …
to in vivo tissue to observe real cell behaviors. We established a novel cell culture platform …
Specificity models in MAPK cascade signaling
Y Ma, J Nicolet - FEBS Open Bio, 2023 - Wiley Online Library
The precise execution of various cellular functions relies on the maintenance of signaling
specificity from input detection to cellular outputs. However, diverse signaling pathways …
specificity from input detection to cellular outputs. However, diverse signaling pathways …
A guide to ERK dynamics, part 2: downstream decoding
A Ram, D Murphy, N DeCuzzi, M Patankar… - Biochemical …, 2023 - portlandpress.com
Signaling by the extracellular signal-regulated kinase (ERK) pathway controls many cellular
processes, including cell division, death, and differentiation. In this second installment of a …
processes, including cell division, death, and differentiation. In this second installment of a …
The extracellular matrix stiffening: a trigger of prostate cancer progression and castration resistance?
Simple Summary Prostate cancer is a malignancy that affects a high number of men all over
the world. When indolent, prostate cancer can remain silent for years without needing …
the world. When indolent, prostate cancer can remain silent for years without needing …
Human alveolar hydrogels promote morphological and transcriptional differentiation in iPSC-derived alveolar type 2 epithelial cells
Alveolar type 2 epithelial cells (AT2s) derived from human induced pluripotent stem cells
(iAT2s) have rapidly contributed to our understanding of AT2 function and disease …
(iAT2s) have rapidly contributed to our understanding of AT2 function and disease …
[HTML][HTML] Extracellular matrix stiffness activates mechanosensitive signals but limits breast cancer cell spheroid proliferation and invasion
I Jahin, T Phillips, S Marcotti, MA Gorey… - Frontiers in Cell and …, 2023 - frontiersin.org
Breast cancer is characterized by physical changes that occur in the tumor
microenvironment throughout growth and metastasis of tumors. Extracellular matrix stiffness …
microenvironment throughout growth and metastasis of tumors. Extracellular matrix stiffness …
[HTML][HTML] Tug-of-war via ERK signaling pathway for tissue organization–ERK activation to force generation
AN Nayak, T Hirashima - Current Opinion in Cell Biology, 2023 - Elsevier
Extracellular signal-regulated kinase (ERK) plays a crucial role in regulating collective cell
behaviors observed in diverse biological phenomena. Emerging studies have shed light on …
behaviors observed in diverse biological phenomena. Emerging studies have shed light on …
Optogenetic clustering and membrane translocation of the BcLOV4 photoreceptor
AA Pal, W Benman, TR Mumford… - Proceedings of the …, 2023 - National Acad Sciences
Optogenetic tools respond to light through one of a small number of behaviors including
allosteric changes, dimerization, clustering, or membrane translocation. Here, we describe a …
allosteric changes, dimerization, clustering, or membrane translocation. Here, we describe a …