Mechanotransduction is the ability of a cell to sense mechanical cues from its
microenvironment and convert them into biochemical signals to elicit adaptive transcriptional …

Many of the best-studied actin regulatory proteins use non-covalent means to modulate the
properties of actin. Yet, actin is also susceptible to covalent modifications of its amino acids …

Although numerous long non-coding RNAs (lncRNAs) have been identified in mammals,
many of their biological roles remain to be characterized. Early reports suggest that H19 …

Besides its essential and well established role as a component of the cytoskeleton, actin is
also present in the cell nucleus, where it has been linked to many processes that control …

Cellular senescence is a stable cell cycle arrest that limits the proliferation of pre-cancerous
cells. Here we demonstrate that scaffold-attachment-factor A (SAFA) and the long noncoding …

We previously identified the heterogeneous ribonucleoprotein SAF-A/hnRNP U as a
substrate for DNA-PK, a protein kinase involved in DNA damage response (DDR). Using …

Gene expression in response to stimuli underlies many fundamental processes. However,
how transcription is regulated under these scenarios is largely unknown. Here, we find a …

The nuclear matrix-associated hnRNP U/SAF-A protein has been implicated in diverse
pathways from transcriptional regulation to telomere length control to X inactivation, but the …

Metabolic reprogramming is one of the hallmarks of tumorigenesis. Here, we show that
nuclear myosin 1 (NM1) serves as a key regulator of cellular metabolism. NM1 directly …

Until recently, it was generally assumed that essentially all regulation of transcription takes
place via regions adjacent to the coding region of a gene—namely promoters and …