Cancer treatment with either standard chemotherapy or targeted agents often results in the
emergence of drug-refractory cell populations, ultimately leading to therapy failure. The …

Interferons (IFNs) are pleiotropic cytokines critical for regulation of epithelial cell functions
and for immune system regulation. In cancer, IFNs contribute to tumor-intrinsic and-extrinsic …

Genetic and epigenetic variation, together with transcriptional plasticity, contribute to
intratumour heterogeneity. The interplay of these biological processes and their respective …

Glioblastoma progression in its early stages remains poorly understood. Here, we transfer
PDGFB and genetic barcodes in mouse brain to initiate gliomagenesis and enable direct …

It has been long recognized that cancer cells reprogram their metabolism under hypoxia
conditions due to a shift from oxidative phosphorylation (OXPHOS) to glycolysis in order to …

Drug resistance mediated by clonal evolution is arguably the biggest problem in cancer
therapy today. However, evolving resistance to one drug may come at a cost of decreased …

Spatial properties of tumour growth have profound implications for cancer progression,
therapeutic resistance and metastasis. Yet, how spatial position governs tumour cell division …

Tumours are often composed of a multitude of malignant clones that are genomically
unique, and only a few of them may have the ability to escape cancer therapy and grow as …

Micrometastases of colorectal cancer can remain dormant for years prior to the formation of
actively growing, clinically detectable lesions (ie, colonization). A better understanding of …

The immune system plays a dual role in tumor evolution—it can identify and control nascent
tumor cells in a process called immunosurveillance and can promote tumor progression …