Sudden cardiac death in the young: the molecular autopsy and a practical approach to surviving relatives

C Semsarian, J Ingles, AAM Wilde - European heart journal, 2015 - academic.oup.com
The sudden death of a young, apparently fit and healthy person is amongst the most
challenging scenarios in clinical medicine. Sudden cardiac death (SCD) is a devastating …

[HTML][HTML] Molecular autopsy in victims of inherited arrhythmias

C Semsarian, J Ingles - Journal of arrhythmia, 2016 - Elsevier
Sudden cardiac death (SCD) is a rare but devastating complication of a number of
underlying cardiovascular diseases. While coronary artery disease and acute myocardial …

Sudden death in young adults: an autopsy-based series of a population undergoing active surveillance

RE Eckart, EA Shry, AP Burke, JA McNear… - Journal of the American …, 2011 - jacc.org
Objectives: The purpose of this study was to define the incidence and characterization of
cardiovascular cause of sudden death in the young. Background: The epidemiology of …

Familial cardiological and targeted genetic evaluation: low yield in sudden unexplained death and high yield in unexplained cardiac arrest syndromes

S Kumar, S Peters, T Thompson, N Morgan… - Heart rhythm, 2013 - Elsevier
Background It has been reported that cardiological screening and genetic evaluation in
relatives of families with sudden unexplained death syndrome and unexplained cardiac …

Sudden death in the young: what do we know about it and how to prevent?

C Van Der Werf, IM Van Langen… - Circulation: Arrhythmia …, 2010 - Am Heart Assoc
Sudden death (SD) of children and adults ages 1 to 40 years has received increasing
attention over the past decades. In this report, we provide an overview of this problem …

Key role of the molecular autopsy in sudden unexpected death

C Semsarian, RM Hamilton - Heart Rhythm, 2012 - Elsevier
Sudden Cardiac Death (SCD) is a major and tragic complication of a number of
cardiovascular diseases. While in the older populations, SCD is most frequently caused by …

Post-mortem genetic analysis in juvenile cases of sudden cardiac death

O Campuzano, O Sanchez-Molero, C Allegue… - Forensic science …, 2014 - Elsevier
Background The reason behind a sudden death of a young individual remains unknown in
up to 50% of postmortem cases. Pathogenic mutations in genes encoding heart proteins are …

Efficiency evaluation of a DNA extraction and purification protocol on archival formalin-fixed and paraffin-embedded tissue

A Farrugia, C Keyser, B Ludes - Forensic Science International, 2010 - Elsevier
Formalin-fixed and paraffin-embedded tissue (FF-PET) is an invaluable resource for
retrospective molecular genetic studies, but the extraction of high-quality genomic DNA from …

[PDF][PDF] Sudden arrhythmia death syndrome in young victims: a five-year retrospective review and two-year prospective molecular autopsy study by next-generation …

CM Mak, NS Mok, HC Shum, WK Siu… - Hong Kong …, 2019 - pdfs.semanticscholar.org
Objective: Sudden arrhythmia death syndrome (SADS) accounts for about 30% of causes of
sudden cardiac death (SCD) in young people. In Hong Kong, there are scarce data on …

Identification of a common variant at the NOS1AP locus strongly associated to QT-interval duration

M Eijgelsheim, ALHJ Aarnoudse… - Human molecular …, 2009 - academic.oup.com
QT-interval prolongation is an electrophysiologic phenomenon associated with sudden
cardiac death. The QT-interval in the general population is∼ 35% heritable. In genome-wide …