[HTML][HTML] Mechanism and evolution of human ACE2 binding by SARS-CoV-2 spike
AG Wrobel - Current Opinion in Structural Biology, 2023 - Elsevier
Spike glycoprotein of SARS-CoV-2 mediates viral entry into host cells by facilitating virus
attachment and membrane fusion. ACE2 is the main receptor of SARS-CoV-2 and its …
attachment and membrane fusion. ACE2 is the main receptor of SARS-CoV-2 and its …
Bottom-up assembly of viral replication cycles
Bottom-up synthetic biology provides new means to understand living matter by constructing
minimal life-like systems. This principle can also be applied to study infectious diseases …
minimal life-like systems. This principle can also be applied to study infectious diseases …
The free fatty acid–binding pocket is a conserved hallmark in pathogenic β-coronavirus spike proteins from SARS-CoV to Omicron
As coronavirus disease 2019 (COVID-19) persists, severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) emerge, accumulating spike (S) …
coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) emerge, accumulating spike (S) …
Therapeutic strategy targeting host lipolysis limits infection by SARS-CoV-2 and influenza A virus
YB Baek, HJ Kwon, M Sharif, J Lim, IC Lee… - … and Targeted Therapy, 2022 - nature.com
The biosynthesis of host lipids and/or lipid droplets (LDs) has been studied extensively as a
putative therapeutic target in diverse viral infections. However, directly targeting the LD …
putative therapeutic target in diverse viral infections. However, directly targeting the LD …
Graphene sandwich–based biological specimen preparation for cryo-EM analysis
J Xu, X Gao, L Zheng, X Jia, K Xu… - Proceedings of the …, 2024 - National Acad Sciences
High-quality specimen preparation plays a crucial role in cryo-electron microscopy (cryo-
EM) structural analysis. In this study, we have developed a reliable and convenient …
EM) structural analysis. In this study, we have developed a reliable and convenient …
Dynamical nonequilibrium molecular dynamics simulations identify allosteric sites and positions associated with drug resistance in the SARS-CoV-2 main protease
HTH Chan, ASF Oliveira, CJ Schofield, AJ Mulholland… - Jacs Au, 2023 - ACS Publications
The SARS-CoV-2 main protease (Mpro) plays an essential role in the coronavirus lifecycle
by catalyzing hydrolysis of the viral polyproteins at specific sites. Mpro is the target of drugs …
by catalyzing hydrolysis of the viral polyproteins at specific sites. Mpro is the target of drugs …
[PDF][PDF] Cryo-EM reveals binding of linoleic acid to SARS-CoV-2 spike glycoprotein, suggesting an antiviral treatment strategy
The COVID-19 pandemic and concomitant lockdowns presented a global health challenge
and triggered unprecedented research efforts to elucidate the molecular mechanisms and …
and triggered unprecedented research efforts to elucidate the molecular mechanisms and …
Sequential appearance and isolation of a SARS-CoV-2 recombinant between two major SARS-CoV-2 variants in a chronically infected immunocompromised patient
Genetic recombination is a major evolutionary mechanism among RNA viruses, and it is
common in coronaviruses, including those infecting humans. A few SARS-CoV-2 …
common in coronaviruses, including those infecting humans. A few SARS-CoV-2 …
SARS-CoV-2 spike variants differ in their allosteric responses to linoleic acid
ASF Oliveira, DK Shoemark… - Journal of molecular …, 2023 - academic.oup.com
The SARS-CoV-2 spike protein contains a functionally important fatty acid (FA) binding site,
which is also found in some other coronaviruses, eg SARS-CoV and MERS-CoV. The …
which is also found in some other coronaviruses, eg SARS-CoV and MERS-CoV. The …
Allosteric modulation by the fatty acid site in the glycosylated SARS-CoV-2 spike
The trimeric spike protein plays an essential role in the SARS-CoV-2 virus lifecycle,
facilitating virus entry through binding to the cellular receptor angiotensin-converting …
facilitating virus entry through binding to the cellular receptor angiotensin-converting …