Streptococcus pneumoniae inflicts a huge disease burden as the leading cause of
community-acquired pneumonia and meningitis. Soon after mainstream antibiotic usage …

Streptococcus suis is a zoonotic agent that causes sepsis and meningitis in pigs and
humans. S. suis infections are responsible for large economic losses in pig production. The …

A family of novel mobile DNA elements is described, examples of which are found at several
independent locations and encode a variety of antibiotic resistance genes. The complete …

Sulfonamides were the first drugs acting selectively on bacteria which could be used
systemically. Today they are infrequently used, in part due to widespread resistance. The …

Trimethoprim (TMP) and sulfonamides (SULs) are synthetic antibacterial agents. The first
SUL compounds were used in 1932, whereas TMP is a relatively new compound first used …

Recent advances in microbial genomics, synthetic organic chemistry and X-ray
crystallography provided opportunities to identify novel antibacterial targets for the …

Sulfonamides and trimethoprim have been used for many decades as efficient and
inexpensive antibacterial agents for animals and man. Resistance to both has, however …

The geographic distribution of pneumococci resistant to one or more of the antibiotics
penicillin, erythromycin, trimethoprim-sulfamethoxazole, and tetracycline appears to be …

Plasmodium falciparum causes the most severe form of malaria in humans. An important
class of drugs in malaria treatment is the sulfone/sulfonamide group, of which sulfadoxine is …

Sulfonamides were amongst the first clinically useful antibacterial agents to be discovered.
The identification of sulfanilamide as the active component of the dye Prontosil rubrum led to …