Three-dimensional genome structures play a key role in gene regulation and cell functions.
Characterization of genome structures necessitates single-cell measurements. This has …

Higher-order genome organization and its variation in different cellular conditions remain
poorly understood. Recent high-coverage genome-wide chromatin interaction mapping …

How spatial chromosome organization influences genome integrity is still poorly understood.
Here, we show that DNA double-strand breaks (DSBs) mediated by topoisomerase 2 (TOP2) …

The binding of the transcriptional regulator CTCF to the genome has been implicated in the
formation of topologically associated domains (TADs). However, the general mechanisms of …

Abstract Characterization of the spatiotemporal properties of the chromatin is essential to
gaining insights into the physical bases of gene co-expression, transcriptional regulation …

Transcriptional regulation of the HOXA genes is thought to involve CTCF-mediated
chromatin loops and the opposing actions of the COMPASS and Polycomb epigenetic …

Genes that regulate hematopoietic stem cell (HSC) self-renewal, proliferation, and
differentiation are tightly controlled by regulatory regions. However, mapping such regions …

Advances in chromosome conformation capture techniques as well as computational
characterization of genomic loci structural dynamics open new opportunities for exploring …

Objective The risk loci for juvenile idiopathic arthritis (JIA) consist of extended haplotypes
that include functional elements in addition to canonical coding genes. As with most …

Proper gene regulation is crucial for cellular differentiation, and dysregulation of key genes
can lead to diseased states such as cancer. The HOX transcription factors play such a role …