Anisotropic microarchitectures arising from an aligned organization of threadlike
extracellular matrix (ECM) components or cells are ubiquitous in the human body, such as …

In the modern world, myocardial infarction is one of the most common cardiovascular
diseases, which are responsible for around 18 million deaths every year or almost 32% of all …

Aims We have shown that human cardiac muscle patches (hCMPs) containing three
different types of cardiac cells—cardiomyocytes (CMs), smooth muscle cells (SMCs), and …

To progress cardiac tissue engineering strategies closer to the clinic, thicker constructs are
required to meet the functional need following a cardiac event. Consequently, pre …

Cardiomyocytes (CMs), endothelial cells (ECs), smooth-muscle cells (SMCs), and cardiac
fibroblasts (CFs) differentiated from human induced-pluripotent stem cells (hiPSCs) are the …

Background: Three-dimensional cell culture systems hold great promise for bridging the gap
between in vitro cell-based model systems and small animal models to study tissue biology …

Many challenges remain in the preclinical evaluation, adjudication, and prioritization of
novel compounds in therapeutic discovery pipelines. These obstacles are evident by the …

The engineered myocardial tissues produced via most manufacturing techniques are
typically just a few dozen micrometers thick, which is too thin for therapeutic applications in …

Despite the overwhelming use of cellularized therapeutics in cardiac regenerative
engineering, approaches to biomanufacture engineered cardiac tissues (ECTs) at clinical …

Human cardiac-muscle patches (hCMPs) constructed from induced pluripotent stem cells
derived cardiomyocytes (iCMs) can replicate the genetics of individual patients, and …