Nucleobase modifications are prevalent in eukaryotic mRNA and their discovery has
resulted in the emergence of epitranscriptomics as a research field. The most abundant …

An increasing number of studies are describing potential uses of circulating tumour DNA
(ctDNA) in the care of patients with colorectal cancer. Owing to this rapidly developing area …

Over the past few decades, substantial evidence has convincingly revealed the existence of
cancer stem cells (CSCs) as a minor subpopulation in cancers, contributing to an aberrantly …

Lung cancer is the leading cause of cancer-related mortality worldwide, and its
tumorigenesis involves the accumulation of genetic and epigenetic events in the respiratory …

One type of RNA editing converts adenosines to inosines (A→ I editing) in double-stranded
RNA (dsRNA) substrates. A→ I RNA editing is mediated by adenosine deaminase acting on …

Summary Adenosine-to-inosine (A-to-I) RNA editing is a widespread post-transcriptional
mechanism, but its genomic landscape and clinical relevance in cancer have not been …

A better understanding of human hepatocellular carcinoma (HCC) pathogenesis at the
molecular level will facilitate the discovery of tumor-initiating events. Transcriptome …

RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …

Genomic mutations in key genes are known to drive tumorigenesis and have been the focus
of much attention in recent years. However, genetic content also may change farther …

Abstract Background N 6-methyladenosine (m6A) and adenosine-to-inosine (A-to-I) RNA
editing are two of the most abundant RNA modification events affecting adenosines in …