The measurement of cell proliferation in vivo is usually carried out by the examination of
static measures. These comprise the mitotic index or labeling indices using incorporation of …

In order to efficiently characterize both antiproliferative potency and mechanism of action of
small molecules targeting the cell cycle, we developed a high-throughput image-based …

Mice are one of the most important model organisms for studying biological phenomena and
diseases processes in life sciences. The biomedical research community has succeeded in …

Phenotypically identical mammalian cells often display considerable variability in transcript
levels of individual genes. How transcriptional activity propagates in cell lineages, and how …

Neurons are postmitotic cells. Reactivation of the cell cycle by neurons has been reported in
Alzheimer's disease (AD) brains and models. This gave rise to the hypothesis that reentering …

Purpose Chromatin remodeling plays an essential role in regulating transcriptional networks
and timing of gene expression. Chromatin remodelers such as SWItch/Sucrose Non …

The influence of process strategies on the dynamics of cell population heterogeneities in
mammalian cell culture is still not well understood. We recently found that the progression of …

The extraction of fluorescence time course data is a major bottleneck in high-throughput live-
cell microscopy. Here we present an extendible framework based on the open-source image …

Polyploidization, a common event during the evolution of different tumours, has been
proposed to confer selective advantages to tumour cells by increasing the occurrence of …

Metastasis is a highly dynamic process during which cancer and microenvironmental cells
undergo a cascade of events required for efficient dissemination throughout the body …