Limited understanding of human proteoforms with complex posttranslational modifications
and the underlying mechanisms poses a major obstacle to research on human health and …

The central dogma of modern biology underscores the pivotal roles proteins play in diverse
biological processes, the study of which necessitates advanced methods to produce …

During tumor development, promoter CpG islands that are normally silenced by Polycomb
repressive complexes (PRCs) become DNA-hypermethylated. The molecular mechanism by …

Epigenetic regulators have a crucial effect on gene expression based on their manipulation
of histone modifications. Histone H2AK119 monoubiquitination (H2AK119Ub), a well …

Abstract DNA methyltransferase 3A (DNMT3A) plays a critical role in establishing and
maintaining DNA methylation patterns in vertebrates. Here we structurally and biochemically …

Synovial sarcoma is an aggressive soft-tissue malignancy that is characterized by a
pathognomonic t (X; 18)(p11. 2; q11. 2) translocation, which produces the fusion oncogene …

SS18-SSX onco-fusion protein formed through aberrant chromosomal translocation t (X, 18;
p11, q11), is the hallmark and plays a critical role in synovial sarcomagenesis. The recent …

Synovial sarcoma (SyS) is an aggressive soft-tissue malignancy characterized by a
pathognomonic chromosomal translocation leading to the formation of the SS18:: SSX …

We describe exciting recent advances in fusion-driven sarcoma etiology, from an
epigenetics perspective. By exploring the current state of the field, we identify and describe …

Abstract The 2-((2-chloroethyl) amino) ethane-1-thiol (CAET)-based chemical trapping
strategy is a practical tool for mechanistic studies of E3-catalysed ubiquitination. However …