DNA topoisomerases: Advances in understanding of cellular roles and multi‐protein complexes via structure‐function analysis
DNA topoisomerases, capable of manipulating DNA topology, are ubiquitous and
indispensable for cellular survival due to the numerous roles they play during DNA …
indispensable for cellular survival due to the numerous roles they play during DNA …
The current case of quinolones: synthetic approaches and antibacterial activity
Quinolones are broad-spectrum synthetic antibacterial drugs first obtained during the
synthesis of chloroquine. Nalidixic acid, the prototype of quinolones, first became available …
synthesis of chloroquine. Nalidixic acid, the prototype of quinolones, first became available …
Topoisomerase II poisons: converting essential enzymes into molecular scissors
KR Vann, AA Oviatt, N Osheroff - Biochemistry, 2021 - ACS Publications
The extensive length, compaction, and interwound nature of DNA, together with its
controlled and restricted movement in eukaryotic cells, create a number of topological issues …
controlled and restricted movement in eukaryotic cells, create a number of topological issues …
Topoisomerase II and leukemia
MJ Pendleton, RH Lindsey Jr, CA Felix… - Annals of the New …, 2014 - Wiley Online Library
Type II topoisomerases are essential enzymes that modulate DNA under‐and overwinding,
knotting, and tangling. Beyond their critical physiological functions, these enzymes are the …
knotting, and tangling. Beyond their critical physiological functions, these enzymes are the …
Structure of a topoisomerase II–DNA–nucleotide complex reveals a new control mechanism for ATPase activity
BH Schmidt, N Osheroff, JM Berger - Nature structural & molecular …, 2012 - nature.com
Type IIA topoisomerases control DNA supercoiling and disentangle chromosomes through a
complex ATP-dependent strand-passage mechanism. Although a general framework exists …
complex ATP-dependent strand-passage mechanism. Although a general framework exists …
Gene amplification: mechanisms and involvement in cancer
A Matsui, T Ihara, H Suda, H Mikami… - Biomolecular …, 2013 - degruyter.com
Gene amplification was recognized as a physiological process during the development of
Drosophila melanogaster. Intriguingly, mammalian cells use this mechanism to overexpress …
Drosophila melanogaster. Intriguingly, mammalian cells use this mechanism to overexpress …
Recurrent mutations in topoisomerase IIα cause a previously undescribed mutator phenotype in human cancers
Topoisomerases nick and reseal DNA to relieve torsional stress associated with
transcription and replication and to resolve structures such as knots and catenanes …
transcription and replication and to resolve structures such as knots and catenanes …
Genome-wide TOP2A DNA cleavage is biased toward translocated and highly transcribed loci
X Yu, JW Davenport, KA Urtishak, ML Carillo… - Genome …, 2017 - genome.cshlp.org
Type II topoisomerases orchestrate proper DNA topology, and they are the targets of anti-
cancer drugs that cause treatment-related leukemias with balanced translocations. Here, we …
cancer drugs that cause treatment-related leukemias with balanced translocations. Here, we …
Basis for the discrimination of supercoil handedness during DNA cleavage by human and bacterial type II topoisomerases
JY Jian, KD McCarty, JAW Byl… - Nucleic Acids …, 2023 - academic.oup.com
To perform double-stranded DNA passage, type II topoisomerases generate a covalent
enzyme-cleaved DNA complex (ie cleavage complex). Although this complex is a requisite …
enzyme-cleaved DNA complex (ie cleavage complex). Although this complex is a requisite …
Catalytic mechanism of ATP hydrolysis in the ATPase domain of human DNA topoisomerase IIα
M Ogrizek, M Janezic, K Valjavec… - Journal of chemical …, 2022 - ACS Publications
Human DNA topoisomerase IIα is a biological nanomachine that regulates the topological
changes of the DNA molecule and is considered a prime target for anticancer drugs. Despite …
changes of the DNA molecule and is considered a prime target for anticancer drugs. Despite …