DNA topoisomerases: Advances in understanding of cellular roles and multi‐protein complexes via structure‐function analysis

SJ McKie, KC Neuman, A Maxwell - Bioessays, 2021 - Wiley Online Library
DNA topoisomerases, capable of manipulating DNA topology, are ubiquitous and
indispensable for cellular survival due to the numerous roles they play during DNA …

The current case of quinolones: synthetic approaches and antibacterial activity

A Naeem, SL Badshah, M Muska, N Ahmad, K Khan - Molecules, 2016 - mdpi.com
Quinolones are broad-spectrum synthetic antibacterial drugs first obtained during the
synthesis of chloroquine. Nalidixic acid, the prototype of quinolones, first became available …

Topoisomerase II poisons: converting essential enzymes into molecular scissors

KR Vann, AA Oviatt, N Osheroff - Biochemistry, 2021 - ACS Publications
The extensive length, compaction, and interwound nature of DNA, together with its
controlled and restricted movement in eukaryotic cells, create a number of topological issues …

Topoisomerase II and leukemia

MJ Pendleton, RH Lindsey Jr, CA Felix… - Annals of the New …, 2014 - Wiley Online Library
Type II topoisomerases are essential enzymes that modulate DNA under‐and overwinding,
knotting, and tangling. Beyond their critical physiological functions, these enzymes are the …

Structure of a topoisomerase II–DNA–nucleotide complex reveals a new control mechanism for ATPase activity

BH Schmidt, N Osheroff, JM Berger - Nature structural & molecular …, 2012 - nature.com
Type IIA topoisomerases control DNA supercoiling and disentangle chromosomes through a
complex ATP-dependent strand-passage mechanism. Although a general framework exists …

Gene amplification: mechanisms and involvement in cancer

A Matsui, T Ihara, H Suda, H Mikami… - Biomolecular …, 2013 - degruyter.com
Gene amplification was recognized as a physiological process during the development of
Drosophila melanogaster. Intriguingly, mammalian cells use this mechanism to overexpress …

Recurrent mutations in topoisomerase IIα cause a previously undescribed mutator phenotype in human cancers

A Boot, M Liu, N Stantial, V Shah… - Proceedings of the …, 2022 - National Acad Sciences
Topoisomerases nick and reseal DNA to relieve torsional stress associated with
transcription and replication and to resolve structures such as knots and catenanes …

Genome-wide TOP2A DNA cleavage is biased toward translocated and highly transcribed loci

X Yu, JW Davenport, KA Urtishak, ML Carillo… - Genome …, 2017 - genome.cshlp.org
Type II topoisomerases orchestrate proper DNA topology, and they are the targets of anti-
cancer drugs that cause treatment-related leukemias with balanced translocations. Here, we …

Basis for the discrimination of supercoil handedness during DNA cleavage by human and bacterial type II topoisomerases

JY Jian, KD McCarty, JAW Byl… - Nucleic Acids …, 2023 - academic.oup.com
To perform double-stranded DNA passage, type II topoisomerases generate a covalent
enzyme-cleaved DNA complex (ie cleavage complex). Although this complex is a requisite …

Catalytic mechanism of ATP hydrolysis in the ATPase domain of human DNA topoisomerase IIα

M Ogrizek, M Janezic, K Valjavec… - Journal of chemical …, 2022 - ACS Publications
Human DNA topoisomerase IIα is a biological nanomachine that regulates the topological
changes of the DNA molecule and is considered a prime target for anticancer drugs. Despite …