Osteoarthritis comprises several joint disorders characterized by articular cartilage
degeneration and persistent pain, causing disability and economic burden. The incidence of …

Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …

Bone remodeling is tightly regulated by a cross-talk between bone-forming osteoblasts and
bone-resorbing osteoclasts. Osteoblasts and osteoclasts communicate with each other to …

Bone consists of separate inner endosteal and outer periosteal compartments, each with
distinct contributions to bone physiology and each maintaining separate pools of cells owing …

Angiogenesis and neurogenesis play irreplaceable roles in bone repair. Although
biomaterial implantation that mimics native skeletal tissue is extensively studied, the nerve …

The immune and skeletal systems share a variety of molecules, including cytokines,
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …

Joint pain is the defining symptom of osteoarthritis (OA) but its origin and mechanisms
remain unclear. Here, we investigated an unprecedented role of osteoclast-initiated …

The bone marrow contains peripheral nerves that promote haematopoietic regeneration
after irradiation or chemotherapy (myeloablation), but little is known about how this is …

Bone regeneration is a complex process requiring highly orchestrated interactions between
different cells and signals to form new mineralized tissue. Blood vessels serve as a structural …

Periodontium is consisted of root cementum, bone lining the tooth socket, gingiva facing the
tooth, and periodontal ligament (PDL). Its primary functions are support of the tooth and …