The 'EF-hand'Ca2+-binding motif plays an essential role in eukaryotic cellular signalling,
and the proteins containing this motif constitute a large and functionally diverse family. The …

One of the greatest challenges in neuroscience has been to monitor electrical activity and
biochemistry in populations of identified neurons in ViVo. 1 Recent work on new microscopy …

The use of genetically encodable calcium indicator proteins to monitor neuronal activity is
hampered by slow response times and a narrow Ca2+-sensitive range. Here we identify …

Calmodulin (CaM) plays critical roles in cardiomyocytes, regulating Na+ (NaV) and L-type
Ca2+ channels (LTCCs). LTCC dysregulation by mutant CaMs has been implicated in action …

Cardiac troponin C belongs to the EF-hand superfamily of calcium-binding proteins and
plays an essential role in the regulation of muscle contraction and relaxation. To follow …

Ca2+ binding is essential for the biological functions of calmodulin (CaM) as a trigger/sensor
protein to regulate many biological processes in the Ca2+-signaling cascade. A challenge in …

Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a familial
arrhythmogenic syndrome characterized by sudden death. There are several genetic forms …

Troponin C (TnC) belongs to the superfamily of EF-hand (helix–loop–helix) Ca 2+-binding
proteins and is an essential component of the regulatory thin filament complex. In a patient …

Calcium signaling, one of the most widespread signaling mechanisms in cells, is generally
carried out by EF-hand proteins, characterized by a helix–loop–helix motif paired in …

The abnormally regulated release of Ca2+ from an intracellular Ca2+ store, the
sarcoplasmic reticulum (SR), is the mechanism underlying contractile and relaxation …