Exercise‐based cardiac rehabilitation for adults with heart failure

L Long, IR Mordi, C Bridges, VA Sagar… - Cochrane Database …, 2019 - cochranelibrary.com
Background Chronic heart failure (HF) is a growing global health challenge. People with HF
experience substantial burden that includes low exercise tolerance, poor health‐related …

Contributory risk and management of comorbidities of hypertension, obesity, diabetes mellitus, hyperlipidemia, and metabolic syndrome in chronic heart failure: a …

B Bozkurt, D Aguilar, A Deswal, SB Dunbar… - Circulation, 2016 - Am Heart Assoc
Elevated levels of diastolic BP and especially systolic BP (SBP) are major risk factors for the
development of HF. 18, 19 One of the most impactful observations from the Framingham …

Exercise training in patients with heart failure and preserved ejection fraction: meta-analysis of randomized control trials

A Pandey, A Parashar, DJ Kumbhani… - Circulation: Heart …, 2015 - Am Heart Assoc
Background—Heart failure with preserved ejection fraction (HFPEF) is common and
characterized by exercise intolerance and lack of proven effective therapies. Exercise …

Mitochondrial oxidative stress in aging and healthspan

DF Dai, YA Chiao, DJ Marcinek, HH Szeto… - Longevity & …, 2014 - Springer
The free radical theory of aging proposes that reactive oxygen species (ROS)-induced
accumulation of damage to cellular macromolecules is a primary driving force of aging and a …

Exercise training improves exercise capacity and diastolic function in patients with heart failure with preserved ejection fraction: results of the Ex-DHF (Exercise …

F Edelmann, G Gelbrich, HD Düngen, S Fröhling… - Journal of the American …, 2011 - jacc.org
Objectives: We sought to determine whether structured exercise training (ET) improves
maximal exercise capacity, left ventricular diastolic function, and quality of life (QoL) in …

Chronotropic incompetence: causes, consequences, and management

PH Brubaker, DW Kitzman - Circulation, 2011 - Am Heart Assoc
Chronotropic incompetence (CI), broadly defined as the inability of the heart to increase its
rate commensurate with increased activity or demand, is common in patients with …

Importance of characteristics and modalities of physical activity and exercise in the management of cardiovascular health in individuals with cardiovascular risk factors …

L Vanhees, N Geladas, D Hansen… - European journal of …, 2012 - journals.sagepub.com
In a previous paper, as the first of a series of three on the importance of characteristics and
modalities of physical activity (PA) and exercise in the management of cardiovascular health …

Exercise‐based rehabilitation for heart failure

RS Taylor, VA Sagar, EJ Davies… - Cochrane database …, 2014 - cochranelibrary.com
Background Previous systematic reviews and meta‐analyses consistently show the positive
effect of exercise‐based rehabilitation for heart failure (HF) on exercise capacity; however …

Cardiovascular effects of exercise training: molecular mechanisms

S Gielen, G Schuler, V Adams - Circulation, 2010 - Am Heart Assoc
In the natural habitat of our ancestors, physical activity was not a preventive intervention but
a matter of survival. In this hostile environment with scarce food and ubiquitous dangers …

Reversing the cardiac effects of sedentary aging in middle age—a randomized controlled trial: implications for heart failure prevention

EJ Howden, S Sarma, JS Lawley, M Opondo… - Circulation, 2018 - Am Heart Assoc
Background: Poor fitness in middle age is a risk factor for heart failure, particularly heart
failure with a preserved ejection fraction. The development of heart failure with a preserved …