Public T-cell responses, in which T cells bearing identical T-cell receptors (TCRs) are
observed to dominate the response to the same antigenic epitope in multiple individuals …

ABSTRACT T-cell receptors recognize peptides presented by the major histocompatibility
complex (MHC) on the surface of antigen-presenting cells (APC). The ability of the T-cell …

The adaptive immune system uses several strategies to generate a repertoire of T-and B-cell
antigen receptors with sufficient diversity to recognize the universe of potential pathogens. In …

Public responses where identical T cell receptors (TCRs) are clonally dominant and shared
between different individuals are a common characteristic of CD8+ T cell-mediated …

A keystone of antiviral immunity is CD8+ T cell recognition of viral peptides bound to MHC-I
proteins. The recognition modes of individual T cell receptors (TCRs) have been studied in …

Why some virus-specific CD8 TCR repertoires are diverse and others restricted or
“oligoclonal” has been unknown. We show here that oligoclonality and extreme clonal …

Recognition of cancer antigens drives the clonal expansion of cancer-reactive T cells, which
is thought to contribute to restricted T-cell receptor (TCR) repertoires in tumor-infiltrating …

T cell receptor (TCR) nucleotide sequences are often generated during analyses of T cell
responses to pathogens or autoantigens. The most important region of the TCR is the third …

The spectrum of TCR Vβ usage is compared for primary and recall CD8+ D b PA 224+ T cell
responses in mice with influenza pneumonia. Single-cell RT-PCR established that the same …

Igs contain unique portions, collectively termed idiotypes (Id), that can be recognized by the
immune system. Id expressed by tumor cells in B-cell malignancies can be regarded as …