Matrix metalloproteinases: from molecular mechanisms to physiology, pathophysiology, and pharmacology
LGN de Almeida, H Thode, Y Eslambolchi… - Pharmacological …, 2022 - Elsevier
The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …
Matrix metalloproteinases: biologic activity and clinical implications
AR Nelson, B Fingleton, ML Rothenberg… - Journal of clinical …, 2000 - ascopubs.org
Tumor progression is a complex, multistage process by which a normal cell undergoes
genetic changes that result in phenotypic alterations and the acquisition of the ability to …
genetic changes that result in phenotypic alterations and the acquisition of the ability to …
Metalloproteinases in biology and pathology of the nervous system
Matrix metalloproteinases (MMPs) have been implicated in several diseases of the nervous
system. Here we review the evidence that supports this idea and discuss the possible …
system. Here we review the evidence that supports this idea and discuss the possible …
Design and Therapeutic Application of Matrix Metalloproteinase Inhibitors. (Chem. Rev. 1999, 99, 2735−2776. Published on the Web September 8, 1999).
M Whittaker, CD Floyd, P Brown, AJH Gearing - Chemical reviews, 2001 - ACS Publications
Molecular mechanisms of glioma invasiveness: the role of proteases
JS Rao - Nature Reviews Cancer, 2003 - nature.com
The invasive nature of brain-tumour cells makes an important contribution to the
ineffectiveness of current treatment modalities, as the remaining tumour cells inevitably …
ineffectiveness of current treatment modalities, as the remaining tumour cells inevitably …
Rapid vascular regrowth in tumors after reversal of VEGF inhibition
MR Mancuso, R Davis, SM Norberg… - The Journal of …, 2006 - Am Soc Clin Investig
Inhibitors of VEGF signaling can block angiogenesis and reduce tumor vascularity, but little
is known about the reversibility of these changes after treatment ends. In the present study …
is known about the reversibility of these changes after treatment ends. In the present study …
Development of matrix metalloproteinase inhibitors in cancer therapy
M Hidalgo, SG Eckhardt - Journal of the National Cancer …, 2001 - academic.oup.com
The matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases involved
in the degradation of the extracellular matrix. The MMPs have been implicated in the …
in the degradation of the extracellular matrix. The MMPs have been implicated in the …
Inhibitors of gelatinases (MMP-2 and MMP-9) for the management of hematological malignancies
Abstract Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) are
collectively known as gelatinases whereas MMP-2 is gelatinase-A and MMP-9 is termed as …
collectively known as gelatinases whereas MMP-2 is gelatinase-A and MMP-9 is termed as …
Matrix metalloproteinases: molecular aspects of their roles in tumour invasion and metastasis
S Curran, GI Murray - European journal of cancer, 2000 - Elsevier
The matrix metalloproteinases (MMPs) are a family of proteolytic enzymes, whose
physiological functions include tissue remodelling and embryogenesis. The importance of …
physiological functions include tissue remodelling and embryogenesis. The importance of …
Matrix metalloproteinases in tumorigenesis: an evolving paradigm
H Hua, M Li, T Luo, Y Yin, Y Jiang - Cellular and Molecular Life Sciences, 2011 - Springer
Proteases are crucial for development, tissue remodeling, and tumorigenesis. Matrix
metalloproteinases (MMPs) family, in particular, consists of more than 20 members with …
metalloproteinases (MMPs) family, in particular, consists of more than 20 members with …