From the initial description of platelets in 1882, their propensity to aggregate and to
contribute to thrombosis was apparent. Indeed, excessive platelet aggregation is associated …

Recent clinical data show that the risk of coronary thrombosis after antiplatelet drugs
withdrawal is much higher than that of surgical bleeding if they are continued. In secondary …

Background—We observed that the prodrug clopidogrel was less effective in inhibiting
platelet aggregation with coadministration of atorvastatin during point-of-care platelet …

Integrins are heterodimeric, transmembrane receptors that function as mechanosensors,
adhesion molecules and signal transduction platforms in a multitude of biological processes …

Rationale: The hallmark of severe influenza virus infection is excessive inflammation of the
lungs. Platelets are activated during influenza, but their role in influenza virus pathogenesis …

The advent of advanced molecular modeling software, big data analytics, and high-speed
processing units has led to the exponential evolution of modern drug discovery and better …

A genome-wide association study identified LMO1, which encodes an LIM-domain-only
transcriptional cofactor, as a neuroblastoma susceptibility gene that functions as an …

Perioperative management of chronically anticoagulated patients and/or patients treated
with antiplatelet therapy is a complex medical problem. This review considers the …

Background During percutaneous coronary intervention (PCI), and in non‐ST segment
elevation acute coronary syndromes (NSTEACS), the risk of acute vessel occlusion by …

The number of HIV-1 positive individuals developing some form of HIV-associated
neurocognitive disorder (HAND) is increasing. In these individuals, the integrity of the blood …