Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions

SA Sakowski, EJ Koubek, KS Chen… - Annals of …, 2024 - Wiley Online Library
Neurodegenerative diseases are increasing in prevalence and place a significant burden on
society. The causes are multifactorial and complex, and increasing evidence suggests a …

[HTML][HTML] High-quality models for assessing the effects of environmental pollutants on the nervous system: 3D brain organoids

Y Yan, Z Yang, L Chen - Ecotoxicology and Environmental Safety, 2024 - Elsevier
The prevalence of environmental problems and the increasing risk of human exposure to
environmental pollutants have become a global concern. The increasing environmental …

Avocational exposure associations with ALS risk, survival, and phenotype: A Michigan-based case-control study

SA Goutman, J Boss, DG Jang, C Piecuch… - Journal of the …, 2024 - Elsevier
Introduction Environmental exposures strongly influence ALS risk and identification is
needed to reduce ALS burden. Participation in hobbies and exercise may alter ALS risk and …

Case-control study of environmental toxins and risk of amyotrophic lateral sclerosis involving the national ALS registry

EO Talbott, AM Malek, VC Arena, F Wu… - … Lateral Sclerosis and …, 2024 - Taylor & Francis
Objective: Neurotoxic chemicals are suggested in the etiology of amyotrophic lateral
sclerosis (ALS). We examined the association of environmental and occupational risk factors …

[HTML][HTML] Metal mixtures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a …

DG Jang, J Dou, EJ Koubek, S Teener, L Zhao… - medRxiv, 2024 - ncbi.nlm.nih.gov
Background: The pathogenesis of amyotrophic lateral sclerosis (ALS) involves both genetic
and environmental factors. This study investigates associations between metal measures in …

Mendelian randomization analysis suggests no associations of human herpes viruses with amyotrophic lateral sclerosis

Q Zheng, D Wang, R Lin, Y Chen, H Huang… - Frontiers in …, 2023 - frontiersin.org
Background The causal associations between infections with human herpes viruses (HHVs)
and amyotrophic lateral sclerosis (ALS) has been disputed. This study investigated the …

Update on recent advances in amyotrophic lateral sclerosis

N Riva, T Domi, L Pozzi, C Lunetta, P Schito… - Journal of …, 2024 - Springer
In the last few years, our understanding of disease molecular mechanisms underpinning
ALS has advanced greatly, allowing the first steps in translating into clinical practice novel …

Nanoplastics and Neurodegeneration in ALS

A Eisen, EP Pioro, SA Goutman, MC Kiernan - Brain Sciences, 2024 - mdpi.com
Plastic production, which exceeds one million tons per year, is of global concern. The
constituent low-density polymers enable spread over large distances and micro/nano …

Residential exposure associations with ALS risk, survival, and phenotype: a Michigan-based case-control study

SA Goutman, J Boss, DG Jang, C Piecuch… - … Lateral Sclerosis and …, 2024 - Taylor & Francis
Background: Environmental exposures impact amyotrophic lateral sclerosis (ALS) risk and
progression, a fatal and progressive neurodegenerative disease. Better characterization of …

Occupational lead exposure and amyotrophic lateral sclerosis survival in the Danish National Patient Registry

IW Tang, J Hansen, AS Dickerson… - … Lateral Sclerosis and …, 2024 - Taylor & Francis
Objectives We investigated the relationship between occupational lead exposure and
amyotrophic lateral sclerosis (ALS) survival in Denmark. Methods We identified 2,161 ALS …