Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

A full understanding of Parkinson's Disease etiopathogenesis and of the causes of the
preferential vulnerability of nigrostriatal dopaminergic neurons is still an unsolved puzzle. A …

Alpha-synuclein (αS) is a conformationally plastic protein that reversibly binds to cellular
membranes. It aggregates and is genetically linked to Parkinson's disease (PD). Here, we …

Parkinson's disease (PD), a neurodegenerative disorder characterized by distinct aging-
independent loss of dopaminergic neurons in substantia nigra pars compacta (SNpc) region …

Abstract α-Synuclein (αS) is a presynaptic disordered protein whose aberrant aggregation is
associated with Parkinson's disease. The functional role of αS is still debated, although it …

Dopamine dyshomeostasis has been acknowledged among the determinants of nigrostriatal
neuron degeneration in Parkinson's disease (PD). Several studies in experimental models …

The molecular architecture of α-Synuclein (α-Syn) inclusions, pathognomonic of various
neurodegenerative disorders, remains unclear. α-Syn inclusions were long thought to …

Lipids represent the most abundant molecular type in the brain, with a fat content of∼ 60%
of the dry brain weight in humans. Despite this fact, little attention has been paid to …

Abstract α-Synuclein (αSYN), a pivotal synaptic protein implicated in synucleinopathies such
as Parkinson's disease and Lewy body dementia, undergoes protein phase separation. We …

The aggregation of α-synuclein (αS), a protein abundant at presynaptic terminals, is
associated with a range of highly debilitating neurodegenerative conditions, including …