Nanomedicines have created a paradigm shift in healthcare. Yet fundamental barriers still
exist that prevent or delay the clinical translation of nanomedicines. Critical hurdles …

Cancer immunotherapy, which harnesses the power of the immune system, has shown
immense promise in the fight against malignancies. Messenger RNA (mRNA) stands as a …

Chimeric antigen receptor macrophage (CAR-MΦ) represents a significant advancement in
immunotherapy, especially for treating solid tumors where traditional CAR-T therapies face …

Summary The Chimeric Antigen Receptor (CAR) T cell therapy has emerged as a ground-
breaking immunotherapeutic approach in cancer treatment. To overcome the complexity and …

Lipid nanoparticles (LNPs) have proven themselves as transformative actors in chimeric
antigen receptor (CAR) T cell therapy, surpassing traditional methods and addressing …

The use of a patient's own immune or tumor cells, manipulated ex vivo, enables Ag-or
patient-specific immunotherapy. Despite some clinical successes, there remain significant …

The adoptive transfer of T cells redirected by chimeric antigen receptors (CARs) has made a
dramatic breakthrough in defeating hematological malignancies. However, in solid tumor …

RNA-based therapy has been an expanding area of clinical research since the COVID-19
outbreak. Often, its comparison has been made to DNA-based gene therapy, such as adeno …

In the past decade, adoptive cell therapy with chimeric antigen receptor‐T (CAR‐T) cells has
revolutionized cancer treatment. However, the complexity and high costs involved in …

Immunotherapy has emerged as a promising approach for cancer treatment, and the use of
microRNAs (miRNAs) as therapeutic agents has gained significant attention. In this study …