Down syndrome is the most common form of intellectual disability and results from one of the
most complex genetic perturbations that is compatible with survival, trisomy 21. The study of …

The dosage of the serine threonine kinase DYRK1A is critical in the central nervous system
(CNS) during development and aging. This review analyzes the functions of this kinase by …

Scope Trisomy for human chromosome 21 results in D own syndrome (DS), which is among
the most complex genetic perturbations leading to intellectual disability. Accumulating data …

Down syndrome (DS) is one of the leading causes of intellectual disability, and patients with
DS face various health issues, including learning and memory deficits, congenital heart …

Down syndrome (trisomy 21) is the most common viable chromosomal disorder with
intellectual impairment and several other developmental abnormalities. Here, we report the …

The corticostriatal pathway that carries sensory, motor, and limbic information to the striatum
plays a critical role in motor control, action selection, and reward. Dysfunction of this …

Down syndrome is the main cause of intellectual disabilities with a large set of comorbidities
from developmental origins but also that appeared across life span. Investigation of the …

Harmine is the β-carboline alkaloid with the highest concentration in the psychotropic plant
decoction Ayahuasca. In rodents, classical antidepressants reverse the symptoms of …

Down syndrome (DS), the most common genetic cause of intellectual disability, is caused by
the trisomy of chromosome 21. MNB/DYRK1A (Minibrain/dual specificity tyrosine …

The gene Dyrk1a is the mammalian ortholog of Drosophila minibrain. Dyrk1a localizes in the
Down syndrome (DS) critical region of chromosome 21q22. 2 and is a major candidate for …