Abstract PAKs, p21-activated kinases, play central roles and act as converging junctions for
discrete signals elicited on the cell surface and for a number of intracellular signaling …

Precise genetic and epigenetic spatiotemporal regulation of gene expression is critical for
proper brain development, function and circuitry formation in the mammalian central nervous …

Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of
worldwide deaths, respectively, due largely to broad increased risk for disease and injury …

Parkinson's disease (PD) is a neurodegenerative, progressive disease without a cure. To
prevent PD onset or at least limit neurodegeneration, a better understanding of the …

Background Over-activated microglia and chronic neuroinflammation contribute to
dopaminergic neuron degeneration and progression of Parkinson's disease (PD). Leucine …

The p21-activated kinases (PAKs), downstream effectors of Ras-related Rho GTPase Cdc42
and Rac, are serine/threonine kinases. Biologically, PAKs participate in various cellular …

The serine/threonine p21-activated kinases (PAKs), as main effectors of the Rho GTPases
Cdc42 and Rac, represent a group of important molecular switches linking the complex …

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), as a long chain non-
coding RNA (lncRNA), has been reported to be upregulated in Parkinson's disease (PD) …

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial
Parkinson disease. Genetics and neuropathology link Parkinson disease with the …

Mutations in Leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson's disease
(PD) and, as such, LRRK2 is considered a promising therapeutic target for age-related …