Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …

The L-type amino acid transporter (LAT) family are Na+-independent transporters, which
deliver neutral amino acids into cells. The four LATs, LAT1 (SLC7A5), LAT2 (SLC7A8), LAT3 …

The L-type amino acid transporter 1 (LAT1 or SLC7A5) transports large neutral amino acids
across the membrane and is crucial for brain drug delivery and tumor growth. LAT1 forms a …

Integrins are heterodimeric cell surface receptors that bind to different extracellular ligands
depending on their composition and regulate all processes which enable multicellular life. In …

Adaptive immunity, a vertebrate specialization, adds memory and exquisite specificity to the
basic innate immune responses present in invertebrates while conserving metabolic …

Alpha (α)-herpesviruses (HSV-1 and HSV-2), like other viruses, are obligate intracellular
parasites. They hijack the cellular machinery to survive and replicate through evading the …

The SLC3A2 gene encodes for a cell-surface transmembrane protein CD98hc (4F2).
CD98hc serves as a chaperone for LAT1 (SLC7A5), LAT2 (SLC7A8), y+ LAT1 (SLC7A7), y+ …

Intestinal CD98 expression plays a crucial role in controlling homeostatic and innate
immune responses in the gut. Modulation of CD98 expression in intestinal cells therefore …

The physiological environment which hosts the conformational conversion of the cellular
prion protein (PrPC) to disease-associated isoforms has remained enigmatic. A quantitative …

The proliferation of antigen-specific lymphocytes and resulting clonal expansion are
essential for adaptive immunity. We report here that B cell–specific deletion of the heavy …