Mammalian Krüppel-like factors in health and diseases

BB McConnell, VW Yang - Physiological reviews, 2010 - journals.physiology.org
The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …

The pathobiology of splicing

AJ Ward, TA Cooper - The Journal of Pathology: A Journal of …, 2010 - Wiley Online Library
Ninety‐four percent of human genes are discontinuous, such that segments expressed as
mRNA are contained within exons and separated by intervening segments, called introns …

VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance

MA ElTanbouly, Y Zhao, E Nowak, J Li, E Schaafsma… - Science, 2020 - science.org
INTRODUCTION A central tenet of the clonal selection theory (CST), the current cornerstone
of adaptive immunity, states that naïve T cells are selected on the basis of specificity to …

A global role for EKLF in definitive and primitive erythropoiesis

D Hodge, E Coghill, J Keys, T Maguire, B Hartmann… - Blood, 2006 - ashpublications.org
Erythroid Kruppel-like factor (EKLF, KLF1) plays an important role in definitive erythropoiesis
and β-globin gene regulation but failure to rectify lethal fetal anemia upon correction of …

Two sides of the same coin: the roles of KLF6 in physiology and pathophysiology

SE Syafruddin, MA Mohtar, WF Wan Mohamad Nazarie… - Biomolecules, 2020 - mdpi.com
The Krüppel-like factors (KLFs) family of proteins control several key biological processes
that include proliferation, differentiation, metabolism, apoptosis and inflammation …

A Germline DNA Polymorphism Enhances Alternative Splicing of the KLF6 Tumor Suppressor Gene and Is Associated with Increased Prostate Cancer Risk

G Narla, A DiFeo, HL Reeves, DJ Schaid, J Hirshfeld… - Cancer research, 2005 - AACR
Prostate cancer is a leading and increasingly prevalent cause of cancer death in men.
Whereas family history of disease is one of the strongest prostate cancer risk factors and …

Krüppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1

D Li, S Yea, S Li, Z Chen, G Narla, M Banck… - Journal of Biological …, 2005 - ASBMB
Preadipocyte differentiation occurs during distinct periods of human development and is a
key determinant of body mass. Transcriptional events underlying adipogenesis continue to …

Zinc and cancer: implications for LIV-1 in breast cancer

BJ Grattan, HC Freake - Nutrients, 2012 - mdpi.com
Zinc is a trace mineral which is vital for the functioning of numerous cellular processes, is
critical for growth, and may play an important role in cancer etiology and outcome. The …

Genomic models of metastatic cancer: functional analysis of death-from-cancer signature genes reveals aneuploid, anoikis-resistant, metastasis-enabling phenotype …

GV Glinsky - Cell cycle, 2006 - Taylor & Francis
A recent discovery of death-from-cancer signature genes identifies potential markers
predicting the high likelihood of treatment failure in cancer patients. This knowledge …

Transcription factors in cancer: when alternative splicing determines opposite cell fates

S Belluti, G Rigillo, C Imbriano - Cells, 2020 - mdpi.com
Alternative splicing (AS) is a finely regulated mechanism for transcriptome and proteome
diversification in eukaryotic cells. Correct balance between AS isoforms takes part in …