[HTML][HTML] The dynamics of nerve degeneration and regeneration in a healthy milieu and in diabetes

LB Dahlin - International Journal of Molecular Sciences, 2023 - mdpi.com
Appropriate animal models, mimicking conditions of both health and disease, are needed to
understand not only the biology and the physiology of neurons and other cells under normal …

Atf3 defines a population of pulmonary endothelial cells essential for lung regeneration

TK Niethamer, LI Levin, MP Morley, A Babu, S Zhou… - Elife, 2023 - elifesciences.org
Following acute injury, the capillary vascular bed in the lung must be repaired to reestablish
gas exchange with the external environment. Little is known about the transcriptional and …

Intrinsic heterogeneity in axon regeneration

XQ Fu, WR Zhan, WY Tian, DD Cao… - Biochemical Society …, 2022 - portlandpress.com
The nervous system is composed of a variety of neurons and glial cells with different
morphology and functions. In the mammalian peripheral nervous system (PNS) or the lower …

[HTML][HTML] Aging alters mechanisms underlying voluntary movements in spinal motor neurons of mice, primates, and humans

RW Castro, MC Lopes, RE Settlage, G Valdez - JCI insight, 2023 - ncbi.nlm.nih.gov
Spinal motor neurons have been implicated in the loss of motor function that occurs with
advancing age. However, the cellular and molecular mechanisms that impair the function of …

[HTML][HTML] The transcription factor Ets1 influences axonal growth via regulation of Lcn2

M Gu, X Li, R Wu, X Cheng, S Zhou, X Gu - Molecular Neurobiology, 2024 - Springer
Transcription factors are essential for the development and regeneration of the nervous
system. The current study investigated key regulatory transcription factors in rat spinal cord …

Transcriptional regulation and signaling of type IV IFN with identification of the ISG repertoire in an amphibian model, Xenopus laevis

SN Chen, B Li, Z Gan, KL Wang, L Li… - The Journal of …, 2023 - journals.aai.org
Abstract The type IV IFN (IFN-υ) is reported in vertebrates from fish to primary mammals with
IFN-υR1 and IL-10R2 as receptor subunits. In this study, the proximal promoter of IFN-υ was …

[HTML][HTML] Automatic landmarking identifies new loci associated with face morphology and implicates Neanderthal introgression in human nasal shape

Q Li, J Chen, P Faux, ME Delgado, B Bonfante… - Communications …, 2023 - nature.com
We report a genome-wide association study of facial features in> 6000 Latin Americans
based on automatic landmarking of 2D portraits and testing for association with inter …

[HTML][HTML] MSC-derived mitochondria promote axonal regeneration via Atf3 gene up-regulation by ROS induced DNA double strand breaks at transcription initiation …

Y Zhang, T Xu, J Xie, H Wu, W Hu, X Yuan - Cell Communication and …, 2024 - Springer
Background The repair of peripheral nerve injury poses a clinical challenge, necessitating
further investigation into novel therapeutic approaches. In recent years, bone marrow …

[HTML][HTML] Lampreys and spinal cord regeneration:“a very special claim on the interest of zoologists,” 1830s-present

K Maxson Jones, JR Morgan - Frontiers in Cell and Developmental …, 2023 - frontiersin.org
Employing history of science methods, including analyses of the scientific literature, archival
documents, and interviews with scientists, this paper presents a history of lampreys in …

Activating transcription factor 3 stimulates follicle-stimulating hormone-β expression in vitro but is dispensable for follicle-stimulating hormone production in murine …

CAI Alonso, CD David, C Toufaily, Y Wang… - …, 2023 - academic.oup.com
Abstract Follicle-stimulating hormone (FSH), a dimeric glycoprotein produced by pituitary
gonadotrope cells, regulates spermatogenesis in males and ovarian follicle growth in …