Transcranial magnetic stimulation (TMS) is a powerful tool to probe in vivo brain circuits, as it
allows to assess several cortical properties such as excitability, plasticity and connectivity in …

Hepatic encephalopathy (HE) is a neurological disorder that occurs in patients with liver
insufficiency. However, its pathogenesis has not been fully elucidated. Pharmacotherapy is …

Oxidative stress plays a crucial role in the pathogenesis of hepatic encephalopathy (HE), but
the mechanism remains unclear. GABAergic neurons in substantia nigra pars reticulata …

Although primary degenerative diseases are the main cause of dementia, a non-negligible
proportion of patients is affected by a secondary and potentially treatable cognitive disorder …

Aims Hyperammonemic rats show peripheral inflammation, increased GABAergic
neurotransmission and neuroinflammation in cerebellum and hippocampus which induce …

Hepatic encephalopathy (HE) is a prognostically relevant neuropsychiatric syndrome that
occurs in the course of acute or chronic liver disease. Besides ascites and variceal bleeding …

Enhanced GABAergic neurotransmission contributes to impairment of motor coordination
and gait and of cognitive function in different pathologies, including hyperammonemia and …

Understanding the operation of cortical circuits is an important and necessary task in both
neuroscience and neurorehabilitation. The functioning of the neocortex results from …

Chronic hyperammonemia is a main contributor to the cognitive and motor impairment in
patients with hepatic encephalopathy. Sustained hyperammonemia induces the TNFα …

Hyperammonemia plays a main role in the neurological impairment in cirrhotic patients with
hepatic encephalopathy. Rats with chronic hyperammonemia reproduce the motor …