With global population aging, age-related diseases, especially sarcopenia, have attracted
much attention in recent years. Characterized by low muscle strength, low muscle quantity or …

Autophagy classically functions as a physiological process to degrade cytoplasmic
components, protein aggregates, and/or organelles, as a mechanism for nutrient …

Sarcopenia is the loss of both muscle mass and function with age. Although the molecular
underpinnings of sarcopenia are not fully understood, numerous pathways are implicated …

Sarcopenia is a complex age-associated syndrome of progressive loss of muscle mass and
strength. Although this condition is influenced by many factors, age-related changes in …

Macroautophagy (hereafter autophagy) is a cellular recycling process that degrades
cytoplasmic components, such as protein aggregates and mitochondria, and is associated …

BACKGROUND: Lower extremity peripheral artery disease (PAD) is a growing epidemic
with limited effective treatment options. Here, we provide a single-nuclei atlas of PAD limb …

Volumetric muscle loss (VML) injuries represent a majority of military service member
casualties and are common in civilian populations following blunt and/or penetrating …

Mitochondria are the main sources of energy production for muscle tissues, including
skeletal, cardiac, or smooth muscle, to support their activities. Mitochondrial dysfunction and …

Background This study was designed to develop an understanding of the pathophysiology
of traumatic muscle injury in the context of Western diet (WD; high fat and high sugar) and …

Endurance exercise training improves exercise capacity as well as skeletal muscle and
whole body metabolism, which are hallmarks of high quality-of-life and healthy aging …