Application of Computational Methods in Understanding Mutations in Mycobacterium tuberculosis Drug Resistance
G Mugumbate, B Nyathi, A Zindoga… - Frontiers in Molecular …, 2021 - frontiersin.org
The emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb) impedes the
End TB Strategy by the World Health Organization aiming for zero deaths, disease, and …
End TB Strategy by the World Health Organization aiming for zero deaths, disease, and …
High proportion of RR-TB and mutations conferring RR outside of the RRDR of the rpoB gene detected in GeneXpert MTB/RIF assay positive pulmonary tuberculosis …
GT Akalu, B Tessema, B Petros - Plos one, 2022 - journals.plos.org
Background Globally, TB is the leading cause of infectious disease morbidity and mortality
with many diagnostic uncertainties. Access to affordable and rapid diagnostics remained a …
with many diagnostic uncertainties. Access to affordable and rapid diagnostics remained a …
The Detection of Mutations and Genotyping of Drug-Resistant Mycobacterium tuberculosis Strains Isolated from Patients in the Rural Eastern Cape Province
LM Faye, MC Hosu, S Oostvogels, A Dippenaar… - Infectious disease …, 2023 - mdpi.com
Drug-resistant tuberculosis (DR-TB) is still a major public health concern in South Africa.
Mutations in M. tuberculosis can cause varying levels of phenotypic resistance to anti-TB …
Mutations in M. tuberculosis can cause varying levels of phenotypic resistance to anti-TB …
[HTML][HTML] Distribution and frequency of common mutations in rpoB gene of Mycobacterium tuberculosis detected by Xpert MTB/RIF and identification of residential areas …
CV Sailo, R Lalremruata, Z Sanga, V Fela… - Journal of Clinical …, 2022 - Elsevier
Background Rifampicin resistance (RR) is a surrogate marker of multidrug-resistant
tuberculosis. The aim of this study is to determine the frequency of the commonly mutated …
tuberculosis. The aim of this study is to determine the frequency of the commonly mutated …
Comparison on Major Gene Mutations Related to Rifampicin and Isoniazid Resistance between Beijing and Non-Beijing Strains of Mycobacterium tuberculosis: A …
S Guo, V Chongsuvivatwong, S Lei - Genes, 2022 - mdpi.com
Objective: The Beijing strain of Mycobacterium tuberculosis (MTB) is controversially
presented as the predominant genotype and is more drug resistant to rifampicin and …
presented as the predominant genotype and is more drug resistant to rifampicin and …
Diagnostic Yield of Xpert MTB/RIF Assay Using Bronchoalveolar Lavage Fluid in Detecting Mycobacterium tuberculosis among the Sputum-Scarce Suspected …
Tuberculosis (TB) remains one of the leading causes of death worldwide and is caused by
the single infectious agent Mycobacterium tuberculosis (Mtb). Although sputum is the most …
the single infectious agent Mycobacterium tuberculosis (Mtb). Although sputum is the most …
Characterization of Genetic Variants Associated with Rifampicin Resistance Level in Mycobacterium tuberculosis Clinical Isolates Collected in Guangzhou Chest …
HMA Hameed, C Fang, Z Liu, Y Ju, X Han… - Infection and drug …, 2022 - Taylor & Francis
Objective Rifampicin (RIF)-resistance, a surrogate marker for multidrug-resistant
tuberculosis (TB), is mediated by mutations in the rpoB gene. We aimed to investigate the …
tuberculosis (TB), is mediated by mutations in the rpoB gene. We aimed to investigate the …
Characterization of probes associated with rifampicin resistance in M. tuberculosis detected by GenXpert from a national reference laboratory at Chennai
P Rajendran, MP Kumar, K Thiruvengadam… - Tuberculosis, 2022 - Elsevier
With increasing use of Xpert MTB/RIF a point of care molecular test for simultaneous
detection of TB and resistance to rifampicin, a growing number of rifampicin resistant cases …
detection of TB and resistance to rifampicin, a growing number of rifampicin resistant cases …
EBUS-GS with the GeneXpert MTB/RIF assay for diagnosis of Mycobacterium tuberculosis infection of isolated pulmonary nodules
J Cao, Y Gu, X Wu, L Cheng, L Wang, Q Qu… - European Journal of …, 2023 - Springer
Objective Investigate the use of endobronchial ultrasonography with a guide sheath (EBUS-
GS) combined with Gene Xpert MTB/RIF (Xpert) for diagnosis of Mycobacterium tuberculosis …
GS) combined with Gene Xpert MTB/RIF (Xpert) for diagnosis of Mycobacterium tuberculosis …
The pattern of rpoB gene mutation of Mycobacterium tuberculosis and predictors of rifampicin resistance detected by GeneXpert MTB/RIF assay in Tanzania
PR Torokaa, MV Majigo, H Kileo, L Urio, MR Mbwana… - Plos one, 2024 - journals.plos.org
Introduction Antimicrobial resistance in Mycobacterium tuberculosis (MTB) poses a
significant challenge to tuberculosis (TB) management worldwide. Rifampicin resistance …
significant challenge to tuberculosis (TB) management worldwide. Rifampicin resistance …