Going circular: history, present, and future of circRNAs in cancer
To date, thousands of highly abundant and conserved single-stranded RNA molecules
shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional …
shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional …
Coding, or non-coding, that is the question
L Poliseno, M Lanza, PP Pandolfi - Cell Research, 2024 - nature.com
The advent of high-throughput sequencing uncovered that our genome is pervasively
transcribed into RNAs that are seemingly not translated into proteins. It was also found that …
transcribed into RNAs that are seemingly not translated into proteins. It was also found that …
A novel protein AXIN1-295aa encoded by circAXIN1 activates the Wnt/β-catenin signaling pathway to promote gastric cancer progression
Y Peng, Y Xu, X Zhang, S Deng, Y Yuan, X Luo… - Molecular cancer, 2021 - Springer
Abstract Background Circular RNA (circRNA), a subclass of non-coding RNA, plays a critical
role in cancer tumorigenesis and metastasis. It has been suggested that circRNA acts as a …
role in cancer tumorigenesis and metastasis. It has been suggested that circRNA acts as a …
circ-EIF6 encodes EIF6-224aa to promote TNBC progression via stabilizing MYH9 and activating the Wnt/beta-catenin pathway
The protein-coding ability of circular RNAs (circRNAs) has recently been a hot topic, but the
expression and roles of protein-coding circRNAs in triple-negative breast cancer (TNBC) …
expression and roles of protein-coding circRNAs in triple-negative breast cancer (TNBC) …
Circular RNA translation: novel protein isoforms and clinical significance
S Wen, J Qadir, BB Yang - Trends in molecular medicine, 2022 - cell.com
In recent years, significant attention has focused on circular RNA (circRNA) translation to
determine its clinical significance. Cap-independent translation of circRNAs driven by an …
determine its clinical significance. Cap-independent translation of circRNAs driven by an …
CircSEMA4B inhibits the progression of breast cancer by encoding a novel protein SEMA4B-211aa and regulating AKT phosphorylation
X Wang, W Jian, Q Luo, L Fang - Cell death & disease, 2022 - nature.com
Abstract PI3K/AKT signaling pathway plays an important role in regulating the
tumorigenesis, recurrence, and metastasis of breast cancer (BC). In this study, we …
tumorigenesis, recurrence, and metastasis of breast cancer (BC). In this study, we …
Expanding uncapped translation and emerging function of circular RNA in carcinomas and noncarcinomas
Y Wang, C Wu, Y Du, Z Li, M Li, P Hou, Z Shen, S Chu… - Molecular cancer, 2022 - Springer
Circular RNAs (circRNAs) are classified as noncoding RNAs because they are devoid of a
5'end cap and a 3'end poly (A) tail necessary for cap-dependent translation. However …
5'end cap and a 3'end poly (A) tail necessary for cap-dependent translation. However …
CircRNAs and their regulatory roles in cancers
M Tao, M Zheng, Y Xu, S Ma, W Zhang, S Ju - Molecular Medicine, 2021 - Springer
Circular RNAs (circRNAs), a novel type of non-coding RNAs (ncRNAs), have a covalently
closed circular structure resulting from pre-mRNA back splicing via spliceosome and …
closed circular structure resulting from pre-mRNA back splicing via spliceosome and …
Circular RNAs' cap-independent translation protein and its roles in carcinomas
L He, C Man, S Xiang, L Yao, X Wang, Y Fan - Molecular cancer, 2021 - Springer
Circular RNAs a kind of covalently closed RNA and widely expressed in eukaryotes.
CircRNAs are involved in a variety of physiological and pathological processes, but their …
CircRNAs are involved in a variety of physiological and pathological processes, but their …
[HTML][HTML] Circular RNA in pancreatic cancer: a novel avenue for the roles of diagnosis and treatment
Z Rong, J Xu, S Shi, Z Tan, Q Meng, J Hua, J Liu… - Theranostics, 2021 - ncbi.nlm.nih.gov
Pancreatic cancer (PC), an important cause of cancer-related deaths worldwide, is one of
the most malignant cancers characterized by a dismal prognosis. Circular RNAs (circRNAs) …
the most malignant cancers characterized by a dismal prognosis. Circular RNAs (circRNAs) …