The neurodevelopmental and dopamine hypotheses are leading theories of the
pathoetiology of schizophrenia, but they were developed in isolation. However, since they …

This paper discusses the current evidence from animal and human studies for a central role
of inflammation in schizophrenia. In animal models, pre-or perinatal elicitation of the immune …

Antipsychotic drugs are central to the treatment of schizophrenia and other psychotic
disorders but are ineffective for some patients and associated with side-effects and …

Rationale Psychosocial stressors are a well-documented risk factor for mental illness.
Neuroinflammation, in particular elevated microglial activity, has been proposed to mediate …

The glutamate and dopamine hypotheses are leading theories of the pathoaetiology of
schizophrenia. Both were initially based on indirect evidence from pharmacological studies …

Complex interactions between the immune system and the brain might have important
aetiological and therapeutic implications for neuropsychiatric brain disorders. A possible …

The inflammasome is hypothesized to be a key mediator of the response to physiological
and psychological stressors, and its dysregulation may be implicated in major depressive …

Importance Longitudinal studies have linked the systemic inflammatory markers interleukin 6
(IL-6) and C-reactive protein (CRP) with the risk of developing heart disease and diabetes …

Depression is the most prevalent and among the most debilitating of psychiatric disorders.
The precise neurobiology of this illness is unknown. Several lines of evidence suggest that …

High levels of pro-inflammatory substances such as cytokines have been described in the
blood and cerebrospinal fluid of schizophrenia patients. Animal models of schizophrenia …