Lung cancer immunotherapy: progress, pitfalls, and promises

A Lahiri, A Maji, PD Potdar, N Singh, P Parikh, B Bisht… - Molecular cancer, 2023 - Springer
Lung cancer is the primary cause of mortality in the United States and around the globe.
Therapeutic options for lung cancer treatment include surgery, radiation therapy …

[HTML][HTML] VEGF/VEGFR-targeted therapy and immunotherapy in non-small cell lung cancer: targeting the tumor microenvironment

Y Zhao, S Guo, J Deng, J Shen, F Du… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Non-small cell lung cancer (NSCLC) is the leading cause of death by cancer worldwide.
Despite developments in therapeutic approaches for the past few decades, the 5-year …

[HTML][HTML] Non-small cell lung cancer: current treatment and future advances

C Zappa, SA Mousa - Translational lung cancer research, 2016 - ncbi.nlm.nih.gov
Lung cancer has a poor prognosis; over half of people diagnosed with lung cancer die
within one year of diagnosis and the 5-year survival is less than 18%. Non-small cell lung …

Lung cancer: Biology and treatment options

H Lemjabbar-Alaoui, OUI Hassan, YW Yang… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Lung cancer remains the leading cause of cancer mortality in men and women in the US
and worldwide. About 90% of lung cancer cases are caused by smoking and the use of …

Therapeutic cancer vaccines: advancements, challenges, and prospects

T Fan, M Zhang, J Yang, Z Zhu, W Cao… - Signal Transduction and …, 2023 - nature.com
With the development and regulatory approval of immune checkpoint inhibitors and adoptive
cell therapies, cancer immunotherapy has undergone a profound transformation over the …

Vaccinia virus-mediated cancer immunotherapy: cancer vaccines and oncolytics

ZS Guo, B Lu, Z Guo, E Giehl, M Feist, E Dai… - … for immunotherapy of …, 2019 - Springer
Cancer vaccines and oncolytic immunotherapy are promising treatment strategies with
potential to provide greater clinical benefit to patients with advanced-stage cancer. In …

Cancer-associated mucins: role in immune modulation and metastasis

R Bhatia, SK Gautam, A Cannon, C Thompson… - Cancer and Metastasis …, 2019 - Springer
Mucins (MUC) protect epithelial barriers from environmental insult to maintain homeostasis.
However, their aberrant overexpression and glycosylation in various malignancies facilitate …

Breathing new life into immunotherapy: review of melanoma, lung and kidney cancer

CG Drake, EJ Lipson, JR Brahmer - Nature reviews Clinical oncology, 2014 - nature.com
Previously, clinical approaches to using the immune system against cancer focused on
vaccines that intended to specifically initiate or amplify a host response against evolving …

Mapping lung cancer epithelial-mesenchymal transition states and trajectories with single-cell resolution

LG Karacosta, B Anchang, N Ignatiadis… - Nature …, 2019 - nature.com
Elucidating the spectrum of epithelial-mesenchymal transition (EMT) and mesenchymal-
epithelial transition (MET) states in clinical samples promises insights on cancer progression …

[HTML][HTML] Current state of immunotherapy for non-small cell lung cancer

J Malhotra, SK Jabbour, J Aisner - Translational lung cancer …, 2017 - ncbi.nlm.nih.gov
Lung cancer is the leading cause of cancer mortality and non-small cell lung cancer
(NSCLC) accounts for more than 85% of all lung cancers. Platinum-based doublet …