Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling
events and transcriptional networks that guide a step‐wise process of organ development …

Genome-wide association (GWA) studies have identified multiple loci at which common
variants modestly but reproducibly influence risk of type 2 diabetes (T2D),,,,,,,,,,. Established …

Blood vessels supply developing organs with metabolic sustenance. Here, we demonstrate
a role for blood vessels as a source of developmental signals during pancreatic …

Notch is an evolutionarily conserved local cell signaling mechanism that participates in a
variety of cellular processes: cell fate specification, differentiation, proliferation, apoptosis …

Members of the Notch family of transmembrane receptors play an important role in cell fate
determination. Over the past decade, a role for Notch in the pathogenesis of hematologic …

In the pancreas, Notch signaling is thought to prevent cell differentiation, thereby
maintaining progenitors in an undifferentiated state. Here, we show that Notch renders …

Notch signaling plays a key role in the normal development of many tissues and cell types,
through diverse effects on differentiation, survival, and/or proliferation that are highly …

Classic studies of dissected and recombined embryonic pancreas tissues published four
decades ago suggested that epithelial–mesenchymal cell interactions regulate growth …

The major forms of diabetes are characterized by pancreatic islet β-cell dysfunction and
decreased β-cell numbers, raising hope for cell replacement therapy. Although human islet …