Many standard and targeted therapies, as well as radiotherapy, have been shown to induce
an anti-tumour immune response, and immunotherapies rely on modulating the host …

Pancreatic ductal adenocarcinoma (PDAC) is composed of a minority of malignant cells
within a microenvironment of extracellular matrix, fibroblasts, endothelial cells, and immune …

Abstract Galectin-3 is a 31-kDa lectin that modulates T-cell responses through several
mechanisms, including apoptosis, T-cell receptor (TCR) cross-linking, and TCR …

Stimulator of interferon genes (STING) is a cytosolic receptor that senses both exogenous
and endogenous cytosolic cyclic dinucleotides (CDNs), activating TBK1/IRF3 (interferon …

How tumor-associated macrophages transit from a predominant antitumor M1-like
phenotype to a protumoral M2-like phenotype during the development of pancreatic ductal …

Annexin A2 is a pleiotropic calcium-and anionic phospholipid-binding protein that exists as
a monomer and as a heterotetrameric complex with the plasminogen receptor protein …

Pancreatic ductal adenocarcinoma (PDA) is among the deadliest cancers in the United
States and in the world. Late diagnosis, early metastasis and lack of effective therapy are …

Pancreatic cancer remains one of the most lethal cancers with few treatment options.
Immune-based strategies to treat pancreatic cancer, such as immune checkpoint inhibitors …

Annexin A2 is a 36-kDa protein interfering with multiple cellular processes especially in
cancer progression. The present review aimed to show the relations between Annexin A2 …

Background & Aims Little is known about mechanisms of perineural invasion (PNI) by
pancreatic ductal adenocarcinomas (PDAs) or other tumors. Annexin A2 (ANXA2) regulates …