Identification of bioactive metabolites using activity metabolomics
The metabolome, the collection of small-molecule chemical entities involved in metabolism,
has traditionally been studied with the aim of identifying biomarkers in the diagnosis and …
has traditionally been studied with the aim of identifying biomarkers in the diagnosis and …
Computational metabolomics: a framework for the million metabolome
“Sola dosis facit venenum.” These words of Paracelsus,“the dose makes the poison”, can
lead to a cavalier attitude concerning potential toxicities of the vast array of low abundance …
lead to a cavalier attitude concerning potential toxicities of the vast array of low abundance …
Plant and microbial sciences as key drivers in the development of metabolomics research
A Aharoni, R Goodacre… - Proceedings of the …, 2023 - National Acad Sciences
This year marks the 25th anniversary of the coinage of the term metabolome [SG Oliver et
al., Trends Biotech. 16, 373–378 (1998)]. As the field rapidly advances, it is important to take …
al., Trends Biotech. 16, 373–378 (1998)]. As the field rapidly advances, it is important to take …
Genetics of trans-regulatory variation in gene expression
Heritable variation in gene expression forms a crucial bridge between genomic variation
and the biology of many traits. However, most expression quantitative trait loci (eQTLs) …
and the biology of many traits. However, most expression quantitative trait loci (eQTLs) …
Frontiers of high-throughput metabolomics
Highlights•Metabolomics enables rapid measurements at 10–100 times higher throughput
than proteomics.•The achievable throughput opens entirely new scientific and medical …
than proteomics.•The achievable throughput opens entirely new scientific and medical …
Global Diversity Lines–A Five-Continent Reference Panel of Sequenced Drosophila melanogaster Strains
Reference collections of multiple Drosophila lines with accumulating collections of “omics”
data have proven especially valuable for the study of population genetics and complex trait …
data have proven especially valuable for the study of population genetics and complex trait …
The metabolic domestication syndrome of budding yeast
R Tengölics, B Szappanos… - Proceedings of the …, 2024 - National Acad Sciences
Cellular metabolism evolves through changes in the structure and quantitative states of
metabolic networks. Here, we explore the evolutionary dynamics of metabolic states by …
metabolic networks. Here, we explore the evolutionary dynamics of metabolic states by …
A deep auto-encoder model for gene expression prediction
Background Gene expression is a key intermediate level that genotypes lead to a particular
trait. Gene expression is affected by various factors including genotypes of genetic variants …
trait. Gene expression is affected by various factors including genotypes of genetic variants …
[PDF][PDF] Confronting the catalytic dark matter encoded by sequenced genomes
The post-genomic era has provided researchers with a deluge of protein sequences.
However, a significant fraction of the proteins encoded by sequenced genomes remains …
However, a significant fraction of the proteins encoded by sequenced genomes remains …
IMA genome‑F17: Draft genome sequences of an Armillaria species from Zimbabwe, Ceratocystis colombiana, Elsinoë necatrix, Rosellinia necatrix, two genomes of Sclerotinia minor, short …
The genus Armillaria includes at least 38 species, most of which are facultative necrotrophs
(Gregory and Rishbeth 1991). Pathogenicity of these organisms can result in Armillaria root …
(Gregory and Rishbeth 1991). Pathogenicity of these organisms can result in Armillaria root …