Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Osteoporosis is a highly prevalent disorder characterized by low bone mineral density and
an increased risk of fracture, termed osteoporotic fracture. Notably, bone mineral density …

Abstract Knowledge gained over the past 10 years about the mechanisms that underpin
autophagy has provided a universal framework for studies of diverse physiological and …

Autophagy is an evolutionarily conserved intracellular process, in which domestic cellular
components are selectively digested for the recycling of nutrients and energy. This process …

Bone remodeling is a tightly controlled mechanism in which osteoblasts (OB), the cells
responsible for bone formation, osteoclasts (OC), the cells specialized for bone resorption …

Genome-wide association (GWA) studies have typically focused on the analysis of single
markers, which often lacks the power to uncover the relatively small effect sizes conferred by …

Osteoclasts resorb bone via the ruffled border, whose complex folds are generated by
secretory lysosome fusion with bone-apposed plasma membrane. Lysosomal fusion with the …

Osteoporosis is a common disorder, affecting hundreds of millions of people worldwide, and
characterized by decreased bone mineral density and increased fracture risk. Known …

Osteoporosis (OP) is a disease that weakens bones and has a high morbidity rate
worldwide, which is prevalent among the elderly, particularly, women of postmenopausal …

Macroautophagy/autophagy is a highly regulated process involved in the turnover of
cytosolic components, however its pivotal role in maintenance of bone homeostasis remains …