Background Neonatal hypoxic–ischemic encephalopathy is an important cause of death as
well as long-term disability in survivors. Erythropoietin has been hypothesized to have …

Neonatology is a new field of medical practice, having come into its own in the 1960s. As the
practice has evolved, infants who were previously destined to die now survive, yet their …

During neonatal hypoxic–ischemic brain injury, activation of transcription of a series of
genes is induced to stimulate erythropoiesis, anti-apoptosis, apoptosis, necrosis and …

Allogeneic umbilical cord blood (UCB) has therapeutic potential for cerebral palsy (CP).
Concomitant administration of recombinant human erythropoietin (rhEPO) may boost the …

Background and Purpose—Neuronal replacement has recently gained attention as a
potential therapeutic target under ischemic conditions. However, the oligodendrogenic …

The two most common causes of neonatal brain injury in the United States are extreme
prematurity and hypoxic-ischemic encephalopathy (HIE). In the United States, 1 in 8 babies …

Perinatal hypoxic-ischemic encephalopathy (HIE) remains a major cause of morbidity and
mortality. Moderate hypothermia (33.5° C) is currently the sole established standard …

The survival of preterm infants has steadily improved thanks to advances in perinatal and
neonatal intensive clinical care. The focus is now on finding ways to improve morbidities …

Neonatal hypoxia-ischemia (HI) is one of the major causes of death and/or lifelong
neurobehavioral and cognitive dysfunction. Undoubtedly, brain damage following HI insult is …

Background: Up to 65% of untreated infants suffering from moderate to severe hypoxic-
ischemic encephalopathy (HIE) are at risk of death or major disability. Therapeutic …