Autophagy is a dynamic circulatory system that occurs in all eukaryotic cells. Cytoplasmic
material is transported to lysosomes for degradation and recovery through autophagy. This …

The Hippo pathway, an evolutionarily conserved signalling mechanism, controls organ size
and tumourigenesis. Increasing lines of evidence suggest that autophagy, an important …

Loss of Hippo tumor-suppressor activity and hyperactivation of YAP are commonly observed
in cancers. Inactivating mutations of Hippo kinases MST1/2 are uncommon, and it remains …

Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease, and its incidence is
increasing annually. It is critical to reveal and delineate the molecular mechanism promoting …

The striatin-interacting phosphatase and kinase (STRIPAK) complex is a large, multisubunit
protein phosphatase 2A (PP2A) assembly that integrates diverse cellular signals in the …

Prior studies demonstrated that the irreversible ERBB1/2/4 inhibitor neratinib caused plasma
membrane-associated mutant K-RAS to localize in intracellular vesicles, concomitant with its …

Rationale: The MSTs (mammalian Ste20-like kinases) 1/2 are members of the HIPPO
pathway that act as growth suppressors in adult proliferative diseases. Pulmonary arterial …

Hyperactivation of YAP has been commonly associated with tumorigenesis, and emerging
evidence hints at multilayered Hippo-independent regulations of YAP. In this study, we …

Covalent ligands are a versatile class of chemical probes and drugs that can target
noncanonical sites on proteins and display differentiated pharmacodynamic properties …

Striatin-interacting phosphatases and kinases (STRIPAKs) are evolutionarily conserved
supramolecular complexes, which have been implicated in the Hippo signaling pathway. Yet …