Multiple myeloma: Available therapies and causes of drug resistance

V Pinto, R Bergantim, HR Caires, H Seca… - Cancers, 2020 - mdpi.com
Multiple myeloma (MM) is the second most common blood cancer. Treatments for MM
include corticosteroids, alkylating agents, anthracyclines, proteasome inhibitors …

The multiple myelomas—current concepts in cytogenetic classification and therapy

SK Kumar, SV Rajkumar - Nature reviews Clinical oncology, 2018 - nature.com
Multiple myeloma (MM) is a plasma cell neoplasm that accounts for 2% of all haematological
malignancies and predominantly affects older individuals (with a median age at diagnosis of …

Treatment of multiple myeloma with high-risk cytogenetics: a consensus of the International Myeloma Working Group

P Sonneveld, H Avet-Loiseau, S Lonial… - Blood, The Journal …, 2016 - ashpublications.org
Abstract The International Myeloma Working Group consensus updates the definition for
high-risk (HR) multiple myeloma based on cytogenetics Several cytogenetic abnormalities …

Multiple myeloma, version 3.2021, NCCN clinical practice guidelines in oncology

SK Kumar, NS Callander, K Adekola… - Journal of the National …, 2020 - jnccn.org
Multiple myeloma is a malignant neoplasm of plasma cells that accumulate in bone marrow,
leading to bone destruction and marrow failure. This manuscript discusses the management …

Management of newly diagnosed symptomatic multiple myeloma: updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) consensus …

JR Mikhael, D Dingli, V Roy, CB Reeder, FK Buadi… - Mayo Clinic …, 2013 - Elsevier
Multiple myeloma remains an incurable neoplasm of plasma cells that affects more than
20,000 people annually in the United States. There has been a veritable revolution in this …

International Myeloma Working Group molecular classification of multiple myeloma: spotlight review

R Fonseca, PL Bergsagel, J Drach, J Shaughnessy… - Leukemia, 2009 - nature.com
Myeloma is a malignant proliferation of monoclonal plasma cells. Although morphologically
similar, several subtypes of the disease have been identified at the genetic and molecular …

Development and validation of a cytogenetic prognostic index predicting survival in multiple myeloma

A Perrot, V Lauwers-Cances, E Tournay… - Journal of Clinical …, 2019 - ascopubs.org
PURPOSE The wide heterogeneity in multiple myeloma (MM) outcome is driven mainly by
cytogenetic abnormalities. The current definition of high-risk profile is restrictive and …

The molecular classification of multiple myeloma

F Zhan, Y Huang, S Colla, JP Stewart, I Hanamura… - Blood, 2006 - ashpublications.org
To better define the molecular basis of multiple myeloma (MM), we performed unsupervised
hierarchic clustering of mRNA expression profiles in CD138-enriched plasma cells from 414 …

Cytogenetic abnormalities in multiple myeloma: association with disease characteristics and treatment response

N Abdallah, SV Rajkumar, P Greipp, P Kapoor… - Blood cancer …, 2020 - nature.com
Cytogenetic abnormalities are found in most multiple myeloma (MM) patients. Although their
prognostic value has been well studied, there are limited data on the association of primary …

Multiple myeloma, version 3.2017, NCCN clinical practice guidelines in oncology

SK Kumar, NS Callander, M Alsina… - Journal of the National …, 2017 - jnccn.org
Multiple myeloma (MM) is caused by the neoplastic proliferation of plasma cells. These
neoplastic plasma cells proliferate and produce monoclonal immunoglobulin in the bone …